ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Peroxisomal acyl-coenzyme A oxidase 1

Intramolecular
Cysteine 297 and cysteine 392
Cysteine 392 and cysteine 396
A redox-regulated disulphide may form within Peroxisomal acyl-coenzyme A oxidase 1 between cysteines 297 and 392.

Details

Redox score ?
65
PDB code
1is2
Structure name
crystal structure of peroxisomal acyl-coa oxidase-ii from rat liver
Structure deposition date
2001-11-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
97
Minimum pKa ?
9
% buried
100
Peptide accession
P07872
Residue number A
297
Residue number B
392
Peptide name
Peroxisomal acyl-coenzyme A oxidase 1

Ligandability

Cysteine 297 of Peroxisomal acyl-coenzyme A oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 392 of Peroxisomal acyl-coenzyme A oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peroxisomal acyl-coenzyme A oxidase 1 between cysteines 392 and 396. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
1is2
Structure name
crystal structure of peroxisomal acyl-coa oxidase-ii from rat liver
Structure deposition date
2001-11-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
92
Minimum pKa ?
13
% buried
100
Peptide accession
P07872
Residue number A
392
Residue number B
396
Peptide name
Peroxisomal acyl-coenzyme A oxidase 1

Ligandability

Cysteine 392 of Peroxisomal acyl-coenzyme A oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 396 of Peroxisomal acyl-coenzyme A oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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