ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Early endosome antigen 1

Intermolecular
Cysteine 1299 and cysteine 1299
Intramolecular
Cysteine 1358 and cysteine 1361
Cysteine 1358 and cysteine 1385
Cysteine 1358 and cysteine 1382
Cysteine 1402 and cysteine 1405
Cysteine 1374 and cysteine 1377
Cysteine 1382 and cysteine 1385
Cysteine 1361 and cysteine 1385
Cysteine 1361 and cysteine 1382
Cysteine 43 and cysteine 46
More...
Cysteine 1377 and cysteine 1402
Cysteine 1374 and cysteine 1402
Cysteine 1377 and cysteine 1405
Cysteine 1358 and cysteine 1402
Cysteine 1385 and cysteine 1402
Cysteine 1374 and cysteine 1385
Cysteine 1358 and cysteine 1374
Cysteine 1385 and cysteine 1405
Cysteine 1377 and cysteine 1385
Cysteine 1374 and cysteine 1405
Cysteine 1361 and cysteine 1402
A redox-regulated disulphide may form between two units of Early endosome antigen 1 at cysteines 1299 and 1299.

Details

Redox score ?
76
PDB code
1joc
Structure name
eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate
Structure deposition date
2001-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
0
Peptide A name
Early endosome antigen 1
Peptide B name
Early endosome antigen 1
Peptide A accession
Q15075
Peptide B accession
Q15075
Peptide A residue number
1299
Peptide B residue number
1299

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1358 and 1361.

Details

Redox score ?
86
PDB code
1joc
Structure name
eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate
Structure deposition date
2001-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
6
% buried
10
Peptide accession
Q15075
Residue number A
1358
Residue number B
1361
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1358 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1361 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1358 and 1385.

Details

Redox score ?
85
PDB code
1joc
Structure name
eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate
Structure deposition date
2001-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
6
% buried
12
Peptide accession
Q15075
Residue number A
1358
Residue number B
1385
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1358 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1385 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1358 and 1382.

Details

Redox score ?
85
PDB code
1joc
Structure name
eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate
Structure deposition date
2001-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
6
% buried
16
Peptide accession
Q15075
Residue number A
1358
Residue number B
1382
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1358 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1382 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1402 and 1405.

Details

Redox score ?
81
PDB code
1joc
Structure name
eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate
Structure deposition date
2001-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
6
% buried
60
Peptide accession
Q15075
Residue number A
1402
Residue number B
1405
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1402 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1405 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1374 and 1377.

Details

Redox score ?
79
PDB code
1joc
Structure name
eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate
Structure deposition date
2001-07-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
77
Minimum pKa ?
5
% buried
nan
Peptide accession
Q15075
Residue number A
1374
Residue number B
1377
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1374 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1377 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1382 and 1385.

Details

Redox score ?
79
PDB code
1joc
Structure name
eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate
Structure deposition date
2001-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
8
% buried
5
Peptide accession
Q15075
Residue number A
1382
Residue number B
1385
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1382 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1385 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1361 and 1385.

Details

Redox score ?
79
PDB code
1joc
Structure name
eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate
Structure deposition date
2001-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
0
Peptide accession
Q15075
Residue number A
1361
Residue number B
1385
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1361 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1385 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1361 and 1382.

Details

Redox score ?
79
PDB code
1joc
Structure name
eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate
Structure deposition date
2001-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
8
% buried
4
Peptide accession
Q15075
Residue number A
1361
Residue number B
1382
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1361 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1382 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 43 and 46.

Details

Redox score ?
77
PDB code
3mjh
Structure name
crystal structure of human rab5a in complex with the c2h2 zinc finger of eea1
Structure deposition date
2010-04-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
8
% buried
20
Peptide accession
Q15075
Residue number A
43
Residue number B
46
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 43 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 46 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1377 and 1402.

Details

Redox score ?
76
PDB code
1joc
Structure name
eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate
Structure deposition date
2001-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
6
% buried
64
Peptide accession
Q15075
Residue number A
1377
Residue number B
1402
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1377 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1402 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1374 and 1402.

Details

Redox score ?
63
PDB code
1joc
Structure name
eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate
Structure deposition date
2001-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
14
% buried
nan
Peptide accession
Q15075
Residue number A
1374
Residue number B
1402
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1374 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1402 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1377 and 1405.

Details

Redox score ?
61
PDB code
1joc
Structure name
eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate
Structure deposition date
2001-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
14
% buried
72
Peptide accession
Q15075
Residue number A
1377
Residue number B
1405
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1377 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1405 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1358 and 1402. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
1joc
Structure name
eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate
Structure deposition date
2001-07-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
6
% buried
34
Peptide accession
Q15075
Residue number A
1358
Residue number B
1402
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1358 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1402 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1385 and 1402. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
1joc
Structure name
eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate
Structure deposition date
2001-07-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
6
% buried
28
Peptide accession
Q15075
Residue number A
1385
Residue number B
1402
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1385 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1402 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1374 and 1385 (28 and 39 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
1hyi
Structure name
solution structure of the eea1 fyve domain complexed with inositol 1, 3-bisphosphate
Structure deposition date
2001-01-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
6
% buried
19
Peptide accession
Q15075
Residue number A
1374
Residue number B
1385
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1374 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1385 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1358 and 1374 (12 and 28 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
1hyi
Structure name
solution structure of the eea1 fyve domain complexed with inositol 1, 3-bisphosphate
Structure deposition date
2001-01-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
6
% buried
24
Peptide accession
Q15075
Residue number A
1358
Residue number B
1374
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1358 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1374 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1385 and 1405 (39 and 59 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
1hyj
Structure name
solution structure of the eea1 fyve domain
Structure deposition date
2001-01-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
4
Peptide accession
Q15075
Residue number A
1385
Residue number B
1405
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1385 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1405 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1377 and 1385 (31 and 39 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
1hyj
Structure name
solution structure of the eea1 fyve domain
Structure deposition date
2001-01-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
4
Peptide accession
Q15075
Residue number A
1377
Residue number B
1385
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1377 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1385 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1374 and 1405. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1joc
Structure name
eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate
Structure deposition date
2001-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
23
% buried
nan
Peptide accession
Q15075
Residue number A
1374
Residue number B
1405
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1374 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1405 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early endosome antigen 1 between cysteines 1361 and 1402 (15 and 56 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
1hyj
Structure name
solution structure of the eea1 fyve domain
Structure deposition date
2001-01-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
6
Peptide accession
Q15075
Residue number A
1361
Residue number B
1402
Peptide name
Early endosome antigen 1

Ligandability

Cysteine 1361 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1402 of Early endosome antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: