Protein disulfide-isomerase A6

Intermolecular

Cysteine 55 and cysteine 248 of Peroxiredoxin-4 L

Intramolecular

A redox-regulated disulphide may form between cysteine 55 of Protein disulfide-isomerase A6 and cysteine 248 of Peroxiredoxin-4 (55 and 2 respectively in this structure).

Details

Redox score ?

PDB code

3w8j

Structure name

crystal structure of p5 a0 in a complex with prx4 c-term

Structure deposition date

2013-03-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Protein disulfide-isomerase A6

Peptide B name

Peroxiredoxin-4

Peptide A accession

Q15084

Peptide B accession

O08807

Peptide A residue number

Peptide B residue number

248

Ligandability

Cysteine 55 of Protein disulfide-isomerase A6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of Peroxiredoxin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein disulfide-isomerase A6 between cysteines 190 and 193.

Details

Redox score ?

PDB code

4gwr

Structure name

crystal structure of the second catalytic domain of protein disulfide isomerase p5

Structure deposition date

2012-09-03

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q15084

Residue number A

190

Residue number B

193

Peptide name

Protein disulfide-isomerase A6

Ligandability

Cysteine 190 of Protein disulfide-isomerase A6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 193 of Protein disulfide-isomerase A6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein disulfide-isomerase A6 between cysteines 55 and 58 (57 and 60 respectively in this structure).