a tool for identifying drug-targetable redox-active disulphides

Platelet-activating factor acetylhydrolase IB subunit alpha1

Intramolecular

Cysteine 55 and cysteine 205 L

A redox-regulated disulphide may form within Platelet-activating factor acetylhydrolase IB subunit alpha1 between cysteines 55 and 205.

Details

Redox score ?

64

PDB code

Structure name

crystal structure of the recombinant alpha1/alpha2 catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase ib

Structure deposition date

2000-09-27

Thiol separation (Å)

5

Half-sphere exposure sum ?

66

Minimum pK_a ?

10

% buried

64

Peptide accession

Residue number A

55

Residue number B

205

Peptide name

Platelet-activating factor acetylhydrolase IB subunit alpha1

Ligandability

Cysteine 55 of Platelet-activating factor acetylhydrolase IB subunit alpha1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of Platelet-activating factor acetylhydrolase IB subunit alpha1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: