ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Advanced glycosylation end product-specific receptor

Intramolecular
Cysteine 38 and cysteine 99
Cysteine 259 and cysteine 301
Cysteine 144 and cysteine 208
A redox-regulated disulphide may form within Advanced glycosylation end product-specific receptor between cysteines 38 and 99.

Details

Redox score ?
85
PDB code
4of5
Structure name
refinement of rage-dna complex in 3s59 without dna
Structure deposition date
2014-01-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15109
Residue number A
38
Residue number B
99
Peptide name
Advanced glycosylation end product-specific receptor

Ligandability

Cysteine 38 of Advanced glycosylation end product-specific receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 99 of Advanced glycosylation end product-specific receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Advanced glycosylation end product-specific receptor between cysteines 259 and 301.

Details

Redox score ?
84
PDB code
4p2y
Structure name
crystal structure of the human rage ectodomain (fragment vc1c2) in complex with mouse s100a6
Structure deposition date
2014-03-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15109
Residue number A
259
Residue number B
301
Peptide name
Advanced glycosylation end product-specific receptor

Ligandability

Cysteine 259 of Advanced glycosylation end product-specific receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 301 of Advanced glycosylation end product-specific receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Advanced glycosylation end product-specific receptor between cysteines 144 and 208.

Details

Redox score ?
80
PDB code
4lp5
Structure name
crystal structure of the full-length human rage extracellular domain (vc1c2 fragment)
Structure deposition date
2013-07-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15109
Residue number A
144
Residue number B
208
Peptide name
Advanced glycosylation end product-specific receptor

Ligandability

Cysteine 144 of Advanced glycosylation end product-specific receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Advanced glycosylation end product-specific receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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