a tool for identifying drug-targetable redox-active disulphides

Programmed cell death protein 1

Intramolecular

Cysteine 54 and cysteine 123

A redox-regulated disulphide may form within Programmed cell death protein 1 between cysteines 54 and 123.

Details

Redox score ?

75

PDB code

Structure name

pd-1 in complex with pembrolizumab fab

Structure deposition date

2016-06-16

Thiol separation (Å)

3

Half-sphere exposure sum ?

82

Minimum pK_a ?

8

% buried

82

Peptide accession

Residue number A

54

Residue number B

123

Peptide name

Programmed cell death protein 1

Ligandability

Cysteine 54 of Programmed cell death protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 123 of Programmed cell death protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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