ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

Intramolecular
Cysteine 78 and cysteine 79
A redox-regulated disulphide may form within Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform between cysteines 78 and 79. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
6nts
Structure name
protein phosphatase 2a (aalpha-b56alpha-calpha) holoenzyme in complex with a small molecule activator of pp2a (smap)
Structure deposition date
2019-01-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
0
Peptide accession
Q15172
Residue number A
78
Residue number B
79
Peptide name
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

Ligandability

Cysteine 78 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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