ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Prostaglandin E synthase 3

Intermolecular
Cysteine 58 and cysteine 58 L
Intramolecular
Cysteine 75 and cysteine 76
A redox-regulated disulphide may form between two units of Prostaglandin E synthase 3 at cysteines 58 and 58.

Details

Redox score ?
75
PDB code
1ejf
Structure name
crystal structure of the human co-chaperone p23
Structure deposition date
2000-03-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide A name
Prostaglandin E synthase 3
Peptide B name
Prostaglandin E synthase 3
Peptide A accession
Q15185
Peptide B accession
Q15185
Peptide A residue number
58
Peptide B residue number
58

Ligandability

A redox-regulated disulphide may form within Prostaglandin E synthase 3 between cysteines 75 and 76. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
1ejf
Structure name
crystal structure of the human co-chaperone p23
Structure deposition date
2000-03-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
66
Peptide accession
Q15185
Residue number A
75
Residue number B
76
Peptide name
Prostaglandin E synthase 3

Ligandability

Cysteine 75 of Prostaglandin E synthase 3

Cysteine 76 of Prostaglandin E synthase 3

If this tool was useful for finding a disulphide, please cite: