ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Receptor-type tyrosine-protein phosphatase R

Intramolecular
Cysteine 500 and cysteine 587
Cysteine 587 and cysteine 596
A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase R between cysteines 500 and 587 (393 and 480 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
1jln
Structure name
crystal structure of the catalytic domain of protein tyrosine phosphatase ptp-sl/br7
Structure deposition date
2001-07-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
9
% buried
96
Peptide accession
Q62132
Residue number A
500
Residue number B
587
Peptide name
Receptor-type tyrosine-protein phosphatase R

Ligandability

Cysteine 500 of Receptor-type tyrosine-protein phosphatase R

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 587 of Receptor-type tyrosine-protein phosphatase R

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase R between cysteines 587 and 596 (480 and 489 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
1jln
Structure name
crystal structure of the catalytic domain of protein tyrosine phosphatase ptp-sl/br7
Structure deposition date
2001-07-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
89
Minimum pKa ?
9
% buried
100
Peptide accession
Q62132
Residue number A
587
Residue number B
596
Peptide name
Receptor-type tyrosine-protein phosphatase R

Ligandability

Cysteine 587 of Receptor-type tyrosine-protein phosphatase R

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 596 of Receptor-type tyrosine-protein phosphatase R

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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