Receptor tyrosine-protein kinase erbB-4
Intramolecular
Cysteine 308 and cysteine 323
Cysteine 326 and cysteine 330
Cysteine 293 and cysteine 304
Cysteine 621 and cysteine 633
Cysteine 234 and cysteine 246
Cysteine 559 and cysteine 577
Cysteine 523 and cysteine 532
Cysteine 593 and cysteine 614
Cysteine 217 and cysteine 229
Cysteine 230 and cysteine 238
More...Cysteine 555 and cysteine 569
Cysteine 29 and cysteine 56
Cysteine 580 and cysteine 589
Cysteine 536 and cysteine 552
Cysteine 156 and cysteine 186
Cysteine 189 and cysteine 197
Cysteine 507 and cysteine 520
Cysteine 503 and cysteine 512
Cysteine 193 and cysteine 205
Cysteine 467 and cysteine 496
Cysteine 617 and cysteine 625
Cysteine 334 and cysteine 359
Cysteine 189 and cysteine 193
Cysteine 249 and cysteine 258
Cysteine 246 and cysteine 258
Cysteine 577 and cysteine 589
Cysteine 213 and cysteine 217
Cysteine 520 and cysteine 532
Cysteine 507 and cysteine 532
Cysteine 217 and cysteine 221
Cysteine 234 and cysteine 258
Cysteine 189 and cysteine 205
Cysteine 262 and cysteine 289
Cysteine 213 and cysteine 221
Cysteine 193 and cysteine 197
Cysteine 238 and cysteine 246
Cysteine 621 and cysteine 625
Cysteine 503 and cysteine 507
Cysteine 577 and cysteine 580
Cysteine 555 and cysteine 559
2ahx B 283 B 298
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 308 and 323 (283 and 298 respectively in this structure).
Details
Redox score ?
89
PDB code
2ahx
Structure name
crystal structure of erbb4/her4 extracellular domain
Structure deposition date
2005-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
308
Residue number B
323
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 308 of Receptor tyrosine-protein kinase erbB-4
Cysteine 323 of Receptor tyrosine-protein kinase erbB-4
3u7u D 301 D 305
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 326 and 330 (301 and 305 respectively in this structure).
Details
Redox score ?
88
PDB code
3u7u
Structure name
crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Structure deposition date
2011-10-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
326
Residue number B
330
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 326 of Receptor tyrosine-protein kinase erbB-4
Cysteine 330 of Receptor tyrosine-protein kinase erbB-4
2ahx A 268 A 279
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 293 and 304 (268 and 279 respectively in this structure).
Details
Redox score ?
88
PDB code
2ahx
Structure name
crystal structure of erbb4/her4 extracellular domain
Structure deposition date
2005-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
293
Residue number B
304
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 293 of Receptor tyrosine-protein kinase erbB-4
Cysteine 304 of Receptor tyrosine-protein kinase erbB-4
2ahx B 596 B 608
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 621 and 633 (596 and 608 respectively in this structure).
Details
Redox score ?
87
PDB code
2ahx
Structure name
crystal structure of erbb4/her4 extracellular domain
Structure deposition date
2005-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
621
Residue number B
633
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 621 of Receptor tyrosine-protein kinase erbB-4
Cysteine 633 of Receptor tyrosine-protein kinase erbB-4
3u9u F 209 F 221
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 234 and 246 (209 and 221 respectively in this structure).
Details
Redox score ?
86
PDB code
3u9u
Structure name
crystal structure of extracellular domain of human erbb4/her4 in complex with the fab fragment of mab1479
Structure deposition date
2011-10-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
234
Residue number B
246
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 234 of Receptor tyrosine-protein kinase erbB-4
Cysteine 246 of Receptor tyrosine-protein kinase erbB-4
2ahx A 534 A 552
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 559 and 577 (534 and 552 respectively in this structure).
Details
Redox score ?
86
PDB code
2ahx
Structure name
crystal structure of erbb4/her4 extracellular domain
Structure deposition date
2005-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
559
Residue number B
577
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 559 of Receptor tyrosine-protein kinase erbB-4
Cysteine 577 of Receptor tyrosine-protein kinase erbB-4
3u7u E 498 E 507
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 523 and 532 (498 and 507 respectively in this structure).
Details
Redox score ?
86
PDB code
3u7u
Structure name
crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Structure deposition date
2011-10-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
523
Residue number B
532
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 523 of Receptor tyrosine-protein kinase erbB-4
Cysteine 532 of Receptor tyrosine-protein kinase erbB-4
2ahx A 568 A 589
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 593 and 614 (568 and 589 respectively in this structure).
Details
Redox score ?
86
PDB code
2ahx
Structure name
crystal structure of erbb4/her4 extracellular domain
Structure deposition date
2005-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
593
Residue number B
614
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 593 of Receptor tyrosine-protein kinase erbB-4
Cysteine 614 of Receptor tyrosine-protein kinase erbB-4
3u9u F 192 F 204
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 217 and 229 (192 and 204 respectively in this structure).
Details
Redox score ?
86
PDB code
3u9u
Structure name
crystal structure of extracellular domain of human erbb4/her4 in complex with the fab fragment of mab1479
Structure deposition date
2011-10-19
Thiol separation (Å)
3
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
22
Peptide accession
Q15303
Residue number A
217
Residue number B
229
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 217 of Receptor tyrosine-protein kinase erbB-4
Cysteine 229 of Receptor tyrosine-protein kinase erbB-4
3u9u E 205 E 213
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 230 and 238 (205 and 213 respectively in this structure).
Details
Redox score ?
85
PDB code
3u9u
Structure name
crystal structure of extracellular domain of human erbb4/her4 in complex with the fab fragment of mab1479
Structure deposition date
2011-10-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
230
Residue number B
238
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 230 of Receptor tyrosine-protein kinase erbB-4
Cysteine 238 of Receptor tyrosine-protein kinase erbB-4
3u7u F 530 F 544
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 555 and 569 (530 and 544 respectively in this structure).
Details
Redox score ?
85
PDB code
3u7u
Structure name
crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Structure deposition date
2011-10-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
555
Residue number B
569
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 555 of Receptor tyrosine-protein kinase erbB-4
Cysteine 569 of Receptor tyrosine-protein kinase erbB-4
3u9u F 4 F 31
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 29 and 56 (4 and 31 respectively in this structure).
Details
Redox score ?
85
PDB code
3u9u
Structure name
crystal structure of extracellular domain of human erbb4/her4 in complex with the fab fragment of mab1479
Structure deposition date
2011-10-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
29
Residue number B
56
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 29 of Receptor tyrosine-protein kinase erbB-4
Cysteine 56 of Receptor tyrosine-protein kinase erbB-4
2ahx A 555 A 564
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 580 and 589 (555 and 564 respectively in this structure).
Details
Redox score ?
85
PDB code
2ahx
Structure name
crystal structure of erbb4/her4 extracellular domain
Structure deposition date
2005-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
580
Residue number B
589
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 580 of Receptor tyrosine-protein kinase erbB-4
Cysteine 589 of Receptor tyrosine-protein kinase erbB-4
2ahx A 511 A 527
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 536 and 552 (511 and 527 respectively in this structure).
Details
Redox score ?
84
PDB code
2ahx
Structure name
crystal structure of erbb4/her4 extracellular domain
Structure deposition date
2005-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
536
Residue number B
552
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 536 of Receptor tyrosine-protein kinase erbB-4
Cysteine 552 of Receptor tyrosine-protein kinase erbB-4
2ahx B 131 B 161
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 156 and 186 (131 and 161 respectively in this structure).
Details
Redox score ?
84
PDB code
2ahx
Structure name
crystal structure of erbb4/her4 extracellular domain
Structure deposition date
2005-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
156
Residue number B
186
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 156 of Receptor tyrosine-protein kinase erbB-4
Cysteine 186 of Receptor tyrosine-protein kinase erbB-4
3u7u E 164 E 172
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 189 and 197 (164 and 172 respectively in this structure).
Details
Redox score ?
84
PDB code
3u7u
Structure name
crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Structure deposition date
2011-10-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
189
Residue number B
197
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 189 of Receptor tyrosine-protein kinase erbB-4
Cysteine 197 of Receptor tyrosine-protein kinase erbB-4
3u7u E 482 E 495
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 507 and 520 (482 and 495 respectively in this structure).
Details
Redox score ?
84
PDB code
3u7u
Structure name
crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Structure deposition date
2011-10-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
507
Residue number B
520
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 507 of Receptor tyrosine-protein kinase erbB-4
Cysteine 520 of Receptor tyrosine-protein kinase erbB-4
2ahx A 478 A 487
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 503 and 512 (478 and 487 respectively in this structure).
Details
Redox score ?
84
PDB code
2ahx
Structure name
crystal structure of erbb4/her4 extracellular domain
Structure deposition date
2005-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
503
Residue number B
512
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 503 of Receptor tyrosine-protein kinase erbB-4
Cysteine 512 of Receptor tyrosine-protein kinase erbB-4
2ahx A 168 A 180
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 193 and 205 (168 and 180 respectively in this structure).
Details
Redox score ?
83
PDB code
2ahx
Structure name
crystal structure of erbb4/her4 extracellular domain
Structure deposition date
2005-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
193
Residue number B
205
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 193 of Receptor tyrosine-protein kinase erbB-4
Cysteine 205 of Receptor tyrosine-protein kinase erbB-4
2ahx A 442 A 471
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 467 and 496 (442 and 471 respectively in this structure).
Details
Redox score ?
83
PDB code
2ahx
Structure name
crystal structure of erbb4/her4 extracellular domain
Structure deposition date
2005-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
467
Residue number B
496
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 467 of Receptor tyrosine-protein kinase erbB-4
Cysteine 496 of Receptor tyrosine-protein kinase erbB-4
3u9u F 592 F 600
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 617 and 625 (592 and 600 respectively in this structure).
Details
Redox score ?
82
PDB code
3u9u
Structure name
crystal structure of extracellular domain of human erbb4/her4 in complex with the fab fragment of mab1479
Structure deposition date
2011-10-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
617
Residue number B
625
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 617 of Receptor tyrosine-protein kinase erbB-4
Cysteine 625 of Receptor tyrosine-protein kinase erbB-4
2ahx A 309 A 334
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 334 and 359 (309 and 334 respectively in this structure).
Details
Redox score ?
82
PDB code
2ahx
Structure name
crystal structure of erbb4/her4 extracellular domain
Structure deposition date
2005-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
334
Residue number B
359
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 334 of Receptor tyrosine-protein kinase erbB-4
Cysteine 359 of Receptor tyrosine-protein kinase erbB-4
3u9u E 164 E 168
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 189 and 193 (164 and 168 respectively in this structure).
Details
Redox score ?
82
PDB code
3u9u
Structure name
crystal structure of extracellular domain of human erbb4/her4 in complex with the fab fragment of mab1479
Structure deposition date
2011-10-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
189
Residue number B
193
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 189 of Receptor tyrosine-protein kinase erbB-4
Cysteine 193 of Receptor tyrosine-protein kinase erbB-4
3u2p A 224 A 233
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 249 and 258 (224 and 233 respectively in this structure).
Details
Redox score ?
81
PDB code
3u2p
Structure name
crystal structure of n-terminal three extracellular domains of erbb4/her4
Structure deposition date
2011-10-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
249
Residue number B
258
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 249 of Receptor tyrosine-protein kinase erbB-4
Cysteine 258 of Receptor tyrosine-protein kinase erbB-4
3u7u E 221 E 233
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 246 and 258 (221 and 233 respectively in this structure).
Details
Redox score ?
78
PDB code
3u7u
Structure name
crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Structure deposition date
2011-10-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
246
Residue number B
258
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 246 of Receptor tyrosine-protein kinase erbB-4
Cysteine 258 of Receptor tyrosine-protein kinase erbB-4
2ahx A 552 A 564
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 577 and 589 (552 and 564 respectively in this structure).
Details
Redox score ?
76
PDB code
2ahx
Structure name
crystal structure of erbb4/her4 extracellular domain
Structure deposition date
2005-07-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
577
Residue number B
589
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 577 of Receptor tyrosine-protein kinase erbB-4
Cysteine 589 of Receptor tyrosine-protein kinase erbB-4
2ahx B 188 B 192
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 213 and 217 (188 and 192 respectively in this structure).
Details
Redox score ?
76
PDB code
2ahx
Structure name
crystal structure of erbb4/her4 extracellular domain
Structure deposition date
2005-07-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
213
Residue number B
217
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 213 of Receptor tyrosine-protein kinase erbB-4
Cysteine 217 of Receptor tyrosine-protein kinase erbB-4
3u7u F 495 F 507
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 520 and 532 (495 and 507 respectively in this structure).
Details
Redox score ?
75
PDB code
3u7u
Structure name
crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Structure deposition date
2011-10-14
Thiol separation (Å)
3
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
520
Residue number B
532
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 520 of Receptor tyrosine-protein kinase erbB-4
Cysteine 532 of Receptor tyrosine-protein kinase erbB-4
2ahx A 482 A 507
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 507 and 532 (482 and 507 respectively in this structure).
Details
Redox score ?
73
PDB code
2ahx
Structure name
crystal structure of erbb4/her4 extracellular domain
Structure deposition date
2005-07-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
507
Residue number B
532
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 507 of Receptor tyrosine-protein kinase erbB-4
Cysteine 532 of Receptor tyrosine-protein kinase erbB-4
3u9u F 192 F 196
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 217 and 221 (192 and 196 respectively in this structure).
Details
Redox score ?
73
PDB code
3u9u
Structure name
crystal structure of extracellular domain of human erbb4/her4 in complex with the fab fragment of mab1479
Structure deposition date
2011-10-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
11
% buried
nan
Peptide accession
Q15303
Residue number A
217
Residue number B
221
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 217 of Receptor tyrosine-protein kinase erbB-4
Cysteine 221 of Receptor tyrosine-protein kinase erbB-4
3u9u F 209 F 233
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 234 and 258 (209 and 233 respectively in this structure).
Details
Redox score ?
72
PDB code
3u9u
Structure name
crystal structure of extracellular domain of human erbb4/her4 in complex with the fab fragment of mab1479
Structure deposition date
2011-10-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
234
Residue number B
258
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 234 of Receptor tyrosine-protein kinase erbB-4
Cysteine 258 of Receptor tyrosine-protein kinase erbB-4
3u9u E 164 E 180
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 189 and 205 (164 and 180 respectively in this structure).
Details
Redox score ?
71
PDB code
3u9u
Structure name
crystal structure of extracellular domain of human erbb4/her4 in complex with the fab fragment of mab1479
Structure deposition date
2011-10-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
189
Residue number B
205
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 189 of Receptor tyrosine-protein kinase erbB-4
Cysteine 205 of Receptor tyrosine-protein kinase erbB-4
3u9u E 237 E 264
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 262 and 289 (237 and 264 respectively in this structure).
Details
Redox score ?
71
PDB code
3u9u
Structure name
crystal structure of extracellular domain of human erbb4/her4 in complex with the fab fragment of mab1479
Structure deposition date
2011-10-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
30
Peptide accession
Q15303
Residue number A
262
Residue number B
289
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 262 of Receptor tyrosine-protein kinase erbB-4
Cysteine 289 of Receptor tyrosine-protein kinase erbB-4
3u9u E 192 E 196
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 213 and 221 (192 and 196 respectively in this structure).
Details
Redox score ?
71
PDB code
3u9u
Structure name
crystal structure of extracellular domain of human erbb4/her4 in complex with the fab fragment of mab1479
Structure deposition date
2011-10-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
nan
Peptide accession
Q15303
Residue number A
213
Residue number B
221
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 213 of Receptor tyrosine-protein kinase erbB-4
Cysteine 221 of Receptor tyrosine-protein kinase erbB-4
3u9u E 168 E 172
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 193 and 197 (168 and 172 respectively in this structure).
Details
Redox score ?
70
PDB code
3u9u
Structure name
crystal structure of extracellular domain of human erbb4/her4 in complex with the fab fragment of mab1479
Structure deposition date
2011-10-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
193
Residue number B
197
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 193 of Receptor tyrosine-protein kinase erbB-4
Cysteine 197 of Receptor tyrosine-protein kinase erbB-4
3u9u F 213 F 221
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 238 and 246 (213 and 221 respectively in this structure).
Details
Redox score ?
70
PDB code
3u9u
Structure name
crystal structure of extracellular domain of human erbb4/her4 in complex with the fab fragment of mab1479
Structure deposition date
2011-10-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
238
Residue number B
246
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 238 of Receptor tyrosine-protein kinase erbB-4
Cysteine 246 of Receptor tyrosine-protein kinase erbB-4
3u7u C 596 C 600
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 621 and 625 (596 and 600 respectively in this structure).
Details
Redox score ?
69
PDB code
3u7u
Structure name
crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Structure deposition date
2011-10-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
621
Residue number B
625
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 621 of Receptor tyrosine-protein kinase erbB-4
Cysteine 625 of Receptor tyrosine-protein kinase erbB-4
3u7u E 478 E 482
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 503 and 507 (478 and 482 respectively in this structure).
Details
Redox score ?
69
PDB code
3u7u
Structure name
crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Structure deposition date
2011-10-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
503
Residue number B
507
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 503 of Receptor tyrosine-protein kinase erbB-4
Cysteine 507 of Receptor tyrosine-protein kinase erbB-4
3u7u A 552 A 555
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 577 and 580 (552 and 555 respectively in this structure).
Details
Redox score ?
68
PDB code
3u7u
Structure name
crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Structure deposition date
2011-10-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
nan
Peptide accession
Q15303
Residue number A
577
Residue number B
580
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 577 of Receptor tyrosine-protein kinase erbB-4
Cysteine 580 of Receptor tyrosine-protein kinase erbB-4
3u7u B 530 B 534
A redox-regulated disulphide may form within Receptor tyrosine-protein kinase erbB-4 between cysteines 555 and 559 (530 and 534 respectively in this structure).
Details
Redox score ?
68
PDB code
3u7u
Structure name
crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Structure deposition date
2011-10-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15303
Residue number A
555
Residue number B
559
Peptide name
Receptor tyrosine-protein kinase erbB-4
Ligandability
Cysteine 555 of Receptor tyrosine-protein kinase erbB-4
Cysteine 559 of Receptor tyrosine-protein kinase erbB-4
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