ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Poly(rC)-binding protein 2

Intramolecular
Cysteine 158 and cysteine 163
Cysteine 109 and cysteine 158 L
A redox-regulated disulphide may form within Poly(rC)-binding protein 2 between cysteines 158 and 163. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2jzx
Structure name
pcbp2 kh1-kh2 domains
Structure deposition date
2008-01-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
50
Peptide accession
Q15366
Residue number A
158
Residue number B
163
Peptide name
Poly(rC)-binding protein 2

Ligandability

Cysteine 158 of Poly(rC)-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 163 of Poly(rC)-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Poly(rC)-binding protein 2 between cysteines 109 and 158. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2jzx
Structure name
pcbp2 kh1-kh2 domains
Structure deposition date
2008-01-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
42
Peptide accession
Q15366
Residue number A
109
Residue number B
158
Peptide name
Poly(rC)-binding protein 2

Ligandability

Cysteine 109 of Poly(rC)-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 158 of Poly(rC)-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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