ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Pumilio homolog 3

Intramolecular
Cysteine 576 and cysteine 610
Cysteine 150 and cysteine 185
A redox-regulated disulphide may form within Pumilio homolog 3 between cysteines 576 and 610.

Details

Redox score ?
65
PDB code
4wzw
Structure name
crystal structure of human puf-a in complex with dna
Structure deposition date
2014-11-20
Thiol separation (Å)
5
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
35
Peptide accession
Q15397
Residue number A
576
Residue number B
610
Peptide name
Pumilio homolog 3

Ligandability

Cysteine 576 of Pumilio homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 610 of Pumilio homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pumilio homolog 3 between cysteines 150 and 185. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
4wzr
Structure name
crystal structure of human puf-a
Structure deposition date
2014-11-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
9
% buried
38
Peptide accession
Q15397
Residue number A
150
Residue number B
185
Peptide name
Pumilio homolog 3

Ligandability

Cysteine 150 of Pumilio homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 185 of Pumilio homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: