a tool for identifying drug-targetable redox-active disulphides

Splicing factor 3A subunit 2

Intramolecular

Cysteine 56 and cysteine 59

A redox-regulated disulphide may form within Splicing factor 3A subunit 2 between cysteines 56 and 59.

Details

Redox score ?

80

PDB code

Structure name

structure of the u2 5' module of the a3'-ssa complex

Structure deposition date

2021-05-25

Thiol separation (Å)

4

Half-sphere exposure sum ?

64

Minimum pK_a ?

6

% buried

63

Peptide accession

Residue number A

56

Residue number B

59

Peptide name

Splicing factor 3A subunit 2

Ligandability

Cysteine 56 of Splicing factor 3A subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 59 of Splicing factor 3A subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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