ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Synaptonemal complex protein 1

Intermolecular
Cysteine 190 and cysteine 190
Cysteine 183 and cysteine 183
Cysteine 703 and cysteine 703
Intramolecular
Cysteine 183 and cysteine 190
A redox-regulated disulphide may form between two units of Synaptonemal complex protein 1 at cysteines 190 and 190.

Details

Redox score ?
82
PDB code
6f62
Structure name
crystal structure of the sycp1 n-terminal head-to-head assembly in open conformation
Structure deposition date
2017-12-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
0
Peptide A name
Synaptonemal complex protein 1
Peptide B name
Synaptonemal complex protein 1
Peptide A accession
Q15431
Peptide B accession
Q15431
Peptide A residue number
190
Peptide B residue number
190

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Synaptonemal complex protein 1 at cysteines 183 and 183.

Details

Redox score ?
77
PDB code
6f62
Structure name
crystal structure of the sycp1 n-terminal head-to-head assembly in open conformation
Structure deposition date
2017-12-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
0
Peptide A name
Synaptonemal complex protein 1
Peptide B name
Synaptonemal complex protein 1
Peptide A accession
Q15431
Peptide B accession
Q15431
Peptide A residue number
183
Peptide B residue number
183

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Synaptonemal complex protein 1 at cysteines 703 and 703.

Details

Redox score ?
75
PDB code
6f63
Structure name
crystal structure of the sycp1 c-terminal back-to-back assembly
Structure deposition date
2017-12-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
7
% buried
72
Peptide A name
Synaptonemal complex protein 1
Peptide B name
Synaptonemal complex protein 1
Peptide A accession
Q15431
Peptide B accession
Q15431
Peptide A residue number
703
Peptide B residue number
703

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Synaptonemal complex protein 1 between cysteines 183 and 190. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6f62
Structure name
crystal structure of the sycp1 n-terminal head-to-head assembly in open conformation
Structure deposition date
2017-12-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
0
Peptide accession
Q15431
Residue number A
183
Residue number B
190
Peptide name
Synaptonemal complex protein 1

Ligandability

Cysteine 183 of Synaptonemal complex protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 190 of Synaptonemal complex protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: