ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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SKI2 subunit of superkiller complex protein

Intramolecular
Cysteine 1117 and cysteine 1199
Cysteine 877 and cysteine 913
A redox-regulated disulphide may form within SKI2 subunit of superkiller complex protein between cysteines 1117 and 1199.

Details

Redox score ?
62
PDB code
7qdr
Structure name
apo human ski complex in the closed state
Structure deposition date
2021-11-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
59
Peptide accession
Q15477
Residue number A
1117
Residue number B
1199
Peptide name
SKI2 subunit of superkiller complex protein

Ligandability

Cysteine 1117 of SKI2 subunit of superkiller complex protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1199 of SKI2 subunit of superkiller complex protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SKI2 subunit of superkiller complex protein between cysteines 877 and 913. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7qdr
Structure name
apo human ski complex in the closed state
Structure deposition date
2021-11-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
34
Peptide accession
Q15477
Residue number A
877
Residue number B
913
Peptide name
SKI2 subunit of superkiller complex protein

Ligandability

Cysteine 877 of SKI2 subunit of superkiller complex protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 913 of SKI2 subunit of superkiller complex protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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