ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ficolin-2

Intramolecular
Cysteine 105 and cysteine 133
Cysteine 257 and cysteine 270
Cysteine 98 and cysteine 126
A redox-regulated disulphide may form within Ficolin-2 between cysteines 105 and 133 (80 and 108 respectively in this structure).

Details

Redox score ?
81
PDB code
2j0h
Structure name
l-ficolin complexed to acetyl-choline
Structure deposition date
2006-08-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15485
Residue number A
105
Residue number B
133
Peptide name
Ficolin-2

Ligandability

Cysteine 105 of Ficolin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Ficolin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ficolin-2 between cysteines 257 and 270 (232 and 245 respectively in this structure).

Details

Redox score ?
77
PDB code
2j1g
Structure name
l-ficolin complexed to n-acetyl-cystein
Structure deposition date
2006-08-11
Thiol separation (Å)
3
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
40
Peptide accession
Q15485
Residue number A
257
Residue number B
270
Peptide name
Ficolin-2

Ligandability

Cysteine 257 of Ficolin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 270 of Ficolin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ficolin-2 between cysteines 98 and 126 (73 and 101 respectively in this structure).

Details

Redox score ?
75
PDB code
2j0g
Structure name
l-ficolin complexed to n-acetyl-mannosamine
Structure deposition date
2006-08-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
nan
Peptide accession
Q15485
Residue number A
98
Residue number B
126
Peptide name
Ficolin-2

Ligandability

Cysteine 98 of Ficolin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Ficolin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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