ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transcription initiation factor TFIID subunit 5

Intermolecular
Cysteine 577 and cysteine 121 of Transcription initiation factor TFIID subunit 9
Intramolecular
Cysteine 273 and cysteine 661
A redox-regulated disulphide may form between cysteine 577 of Transcription initiation factor TFIID subunit 5 and cysteine 121 of Transcription initiation factor TFIID subunit 9. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
7egj
Structure name
scp promoter-bound tfiid-tfiia in post tbp-loading state
Structure deposition date
2021-03-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
94
Peptide A name
Transcription initiation factor TFIID subunit 5
Peptide B name
Transcription initiation factor TFIID subunit 9
Peptide A accession
Q15542
Peptide B accession
Q16594
Peptide A residue number
577
Peptide B residue number
121

Ligandability

Cysteine 577 of Transcription initiation factor TFIID subunit 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of Transcription initiation factor TFIID subunit 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription initiation factor TFIID subunit 5 between cysteines 273 and 661. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7egj
Structure name
scp promoter-bound tfiid-tfiia in post tbp-loading state
Structure deposition date
2021-03-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
91
Peptide accession
Q15542
Residue number A
273
Residue number B
661
Peptide name
Transcription initiation factor TFIID subunit 5

Ligandability

Cysteine 273 of Transcription initiation factor TFIID subunit 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 661 of Transcription initiation factor TFIID subunit 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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