a tool for identifying drug-targetable redox-active disulphides

Transcription elongation factor A protein 2

Intramolecular

Cysteine 135 and cysteine 142

A redox-regulated disulphide may form within Transcription elongation factor A protein 2 between cysteines 135 and 142 (9 and 16 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

46

PDB code

Structure name

solution nmr structure of human transcription elongation factor a protein 2, central domain, northeast structural genomics consortium (nesg) target hr8682b

Structure deposition date

2012-07-20

Thiol separation (Å)

9

Half-sphere exposure sum ?

51

Minimum pK_a ?

9

% buried

22

Peptide accession

Residue number A

135

Residue number B

142

Peptide name

Transcription elongation factor A protein 2

Ligandability

Cysteine 135 of Transcription elongation factor A protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 142 of Transcription elongation factor A protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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