Tumor necrosis factor receptor type 1-associated DEATH domain protein
Intermolecular
Cysteine 381 of Tumor necrosis factor receptor superfamily member 16 and cysteine 241
Intramolecular
Cysteine 135 and cysteine 138
Cysteine 83 and cysteine 135
Cysteine 78 and cysteine 83
7csq A 381 B 241
A redox-regulated disulphide may form between cysteine 381 of Tumor necrosis factor receptor superfamily member 16 and cysteine 241 of Tumor necrosis factor receptor type 1-associated DEATH domain protein. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7csq
Structure name
solution structure of the complex between p75ntr-dd and tradd-dd
Structure deposition date
2020-08-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
74
Peptide A name
Tumor necrosis factor receptor superfamily member 16
Peptide B name
Tumor necrosis factor receptor type 1-associated DEATH domain protein
Peptide A accession
P08138
Peptide B accession
Q15628
Peptide A residue number
381
Peptide B residue number
241
Ligandability
Cysteine 381 of Tumor necrosis factor receptor superfamily member 16
Cysteine 241 of Tumor necrosis factor receptor type 1-associated DEATH domain protein
1f3v A 135 A 138
A redox-regulated disulphide may form within Tumor necrosis factor receptor type 1-associated DEATH domain protein between cysteines 135 and 138. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
1f3v
Structure name
crystal structure of the complex between the n-terminal domain of tradd and the traf domain of traf2
Structure deposition date
2000-06-06
Thiol separation (Å)
6
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
26
Peptide accession
Q15628
Residue number A
135
Residue number B
138
Peptide name
Tumor necrosis factor receptor type 1-associated DEATH domain protein
Ligandability
Cysteine 135 of Tumor necrosis factor receptor type 1-associated DEATH domain protein
Cysteine 138 of Tumor necrosis factor receptor type 1-associated DEATH domain protein
1f3v A 83 A 135
A redox-regulated disulphide may form within Tumor necrosis factor receptor type 1-associated DEATH domain protein between cysteines 83 and 135. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
1f3v
Structure name
crystal structure of the complex between the n-terminal domain of tradd and the traf domain of traf2
Structure deposition date
2000-06-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
56
Peptide accession
Q15628
Residue number A
83
Residue number B
135
Peptide name
Tumor necrosis factor receptor type 1-associated DEATH domain protein
Ligandability
Cysteine 83 of Tumor necrosis factor receptor type 1-associated DEATH domain protein
Cysteine 135 of Tumor necrosis factor receptor type 1-associated DEATH domain protein
1f3v A 78 A 83
A redox-regulated disulphide may form within Tumor necrosis factor receptor type 1-associated DEATH domain protein between cysteines 78 and 83. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
1f3v
Structure name
crystal structure of the complex between the n-terminal domain of tradd and the traf domain of traf2
Structure deposition date
2000-06-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
52
Peptide accession
Q15628
Residue number A
78
Residue number B
83
Peptide name
Tumor necrosis factor receptor type 1-associated DEATH domain protein
Ligandability
Cysteine 78 of Tumor necrosis factor receptor type 1-associated DEATH domain protein
Cysteine 83 of Tumor necrosis factor receptor type 1-associated DEATH domain protein
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