ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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RISC-loading complex subunit TARBP2

Intermolecular
Cysteine 284 of Endoribonuclease Dicer and cysteine 325
Intramolecular
Cysteine 294 and cysteine 295 L
Cysteine 295 and cysteine 325 L
Cysteine 323 and cysteine 325
A redox-regulated disulphide may form between cysteine 284 of Endoribonuclease Dicer and cysteine 325 of RISC-loading complex subunit TARBP2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
5zak
Structure name
cryo-em structure of human dicer and its complexes with a pre-mirna substrate
Structure deposition date
2018-02-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
76
Peptide A name
Endoribonuclease Dicer
Peptide B name
RISC-loading complex subunit TARBP2
Peptide A accession
Q9UPY3
Peptide B accession
Q15633
Peptide A residue number
284
Peptide B residue number
325

Ligandability

Cysteine 284 of Endoribonuclease Dicer

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 325 of RISC-loading complex subunit TARBP2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RISC-loading complex subunit TARBP2 between cysteines 294 and 295.

Details

Redox score ?
66
PDB code
4wyq
Structure name
crystal structure of the dicer-trbp interface
Structure deposition date
2014-11-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
22
Peptide accession
Q15633
Residue number A
294
Residue number B
295
Peptide name
RISC-loading complex subunit TARBP2

Ligandability

Cysteine 294 of RISC-loading complex subunit TARBP2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 295 of RISC-loading complex subunit TARBP2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RISC-loading complex subunit TARBP2 between cysteines 295 and 325. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
4wyq
Structure name
crystal structure of the dicer-trbp interface
Structure deposition date
2014-11-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
54
Peptide accession
Q15633
Residue number A
295
Residue number B
325
Peptide name
RISC-loading complex subunit TARBP2

Ligandability

Cysteine 295 of RISC-loading complex subunit TARBP2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 325 of RISC-loading complex subunit TARBP2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RISC-loading complex subunit TARBP2 between cysteines 323 and 325. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
4wyq
Structure name
crystal structure of the dicer-trbp interface
Structure deposition date
2014-11-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
9
% buried
37
Peptide accession
Q15633
Residue number A
323
Residue number B
325
Peptide name
RISC-loading complex subunit TARBP2

Ligandability

Cysteine 323 of RISC-loading complex subunit TARBP2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 325 of RISC-loading complex subunit TARBP2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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