ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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2'-5'-oligoadenylate synthase-like protein

Intramolecular
Cysteine 329 and cysteine 335
Cysteine 334 and cysteine 335
Cysteine 329 and cysteine 334
A redox-regulated disulphide may form within 2'-5'-oligoadenylate synthase-like protein between cysteines 329 and 335.

Details

Redox score ?
79
PDB code
4xq7
Structure name
the crystal structure of the oas-like domain (old) of human oasl
Structure deposition date
2015-01-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
4
% buried
88
Peptide accession
Q15646
Residue number A
329
Residue number B
335
Peptide name
2'-5'-oligoadenylate synthase-like protein

Ligandability

Cysteine 329 of 2'-5'-oligoadenylate synthase-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 335 of 2'-5'-oligoadenylate synthase-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 2'-5'-oligoadenylate synthase-like protein between cysteines 334 and 335.

Details

Redox score ?
78
PDB code
4xq7
Structure name
the crystal structure of the oas-like domain (old) of human oasl
Structure deposition date
2015-01-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
4
% buried
83
Peptide accession
Q15646
Residue number A
334
Residue number B
335
Peptide name
2'-5'-oligoadenylate synthase-like protein

Ligandability

Cysteine 334 of 2'-5'-oligoadenylate synthase-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 335 of 2'-5'-oligoadenylate synthase-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 2'-5'-oligoadenylate synthase-like protein between cysteines 329 and 334. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
4xq7
Structure name
the crystal structure of the oas-like domain (old) of human oasl
Structure deposition date
2015-01-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
13
% buried
86
Peptide accession
Q15646
Residue number A
329
Residue number B
334
Peptide name
2'-5'-oligoadenylate synthase-like protein

Ligandability

Cysteine 329 of 2'-5'-oligoadenylate synthase-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 334 of 2'-5'-oligoadenylate synthase-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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