ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mediator of RNA polymerase II transcription subunit 1

Intermolecular
Cysteine 464 and cysteine 93 of Mediator of RNA polymerase II transcription subunit 24
Intramolecular
Cysteine 443 and cysteine 464
Cysteine 477 and cysteine 501
A redox-regulated disulphide may form between cysteine 464 of Mediator of RNA polymerase II transcription subunit 1 and cysteine 93 of Mediator of RNA polymerase II transcription subunit 24. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
7enj
Structure name
human mediator (deletion of med1-idr) in a tail-bent conformation (med-b)
Structure deposition date
2021-04-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
90
Peptide A name
Mediator of RNA polymerase II transcription subunit 1
Peptide B name
Mediator of RNA polymerase II transcription subunit 24
Peptide A accession
Q15648
Peptide B accession
O75448
Peptide A residue number
464
Peptide B residue number
93

Ligandability

Cysteine 464 of Mediator of RNA polymerase II transcription subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Mediator of RNA polymerase II transcription subunit 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 1 between cysteines 443 and 464. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7enj
Structure name
human mediator (deletion of med1-idr) in a tail-bent conformation (med-b)
Structure deposition date
2021-04-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
100
Peptide accession
Q15648
Residue number A
443
Residue number B
464
Peptide name
Mediator of RNA polymerase II transcription subunit 1

Ligandability

Cysteine 443 of Mediator of RNA polymerase II transcription subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 464 of Mediator of RNA polymerase II transcription subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 1 between cysteines 477 and 501. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
85
Peptide accession
Q15648
Residue number A
477
Residue number B
501
Peptide name
Mediator of RNA polymerase II transcription subunit 1

Ligandability

Cysteine 477 of Mediator of RNA polymerase II transcription subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 501 of Mediator of RNA polymerase II transcription subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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