ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Activating signal cointegrator 1

Intramolecular
Cysteine 516 and cysteine 541
Cysteine 436 and cysteine 510
Cysteine 510 and cysteine 541
A redox-regulated disulphide may form within Activating signal cointegrator 1 between cysteines 516 and 541 (89 and 114 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2e5o
Structure name
'solution structure of the trip_4c domain of target of activating signal cointegrator 1
Structure deposition date
2006-12-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
74
Peptide accession
Q15650
Residue number A
516
Residue number B
541
Peptide name
Activating signal cointegrator 1

Ligandability

Cysteine 516 of Activating signal cointegrator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 541 of Activating signal cointegrator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activating signal cointegrator 1 between cysteines 436 and 510 (9 and 83 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
2e5o
Structure name
'solution structure of the trip_4c domain of target of activating signal cointegrator 1
Structure deposition date
2006-12-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
88
Peptide accession
Q15650
Residue number A
436
Residue number B
510
Peptide name
Activating signal cointegrator 1

Ligandability

Cysteine 436 of Activating signal cointegrator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 510 of Activating signal cointegrator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activating signal cointegrator 1 between cysteines 510 and 541 (83 and 114 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
2e5o
Structure name
'solution structure of the trip_4c domain of target of activating signal cointegrator 1
Structure deposition date
2006-12-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
90
Peptide accession
Q15650
Residue number A
510
Residue number B
541
Peptide name
Activating signal cointegrator 1

Ligandability

Cysteine 510 of Activating signal cointegrator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 541 of Activating signal cointegrator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: