a tool for identifying drug-targetable redox-active disulphides

Probable JmjC domain-containing histone demethylation protein 2C

Intramolecular

Cysteine 2163 and cysteine 2448

A redox-regulated disulphide may form within Probable JmjC domain-containing histone demethylation protein 2C between cysteines 2163 and 2448.

Details

Redox score ?

83

PDB code

Structure name

crystal structure of the catalytic domain of human jmjd1c

Structure deposition date

2016-03-15

Thiol separation (Å)

2

Half-sphere exposure sum ?

64

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

2163

Residue number B

2448

Peptide name

Probable JmjC domain-containing histone demethylation protein 2C

Ligandability

Cysteine 2163 of Probable JmjC domain-containing histone demethylation protein 2C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2448 of Probable JmjC domain-containing histone demethylation protein 2C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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