ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tryptase alpha/beta-1

Intramolecular
Cysteine 155 and cysteine 230
Cysteine 220 and cysteine 248
Cysteine 188 and cysteine 211
Cysteine 59 and cysteine 75
A redox-regulated disulphide may form within Tryptase alpha/beta-1 between cysteines 155 and 230 (136 and 201 respectively in this structure).

Details

Redox score ?
84
PDB code
2f9o
Structure name
crystal structure of the recombinant human alpha i tryptase mutant d216g
Structure deposition date
2005-12-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15157
Residue number A
155
Residue number B
230
Peptide name
Tryptase alpha/beta-1

Ligandability

Cysteine 155 of Tryptase alpha/beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 230 of Tryptase alpha/beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tryptase alpha/beta-1 between cysteines 220 and 248 (209 and 238 respectively in this structure).

Details

Redox score ?
80
PDB code
4a6l
Structure name
beta-tryptase inhibitor
Structure deposition date
2011-11-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15661
Residue number A
220
Residue number B
248
Peptide name
Tryptase alpha/beta-1

Ligandability

Cysteine 220 of Tryptase alpha/beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of Tryptase alpha/beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tryptase alpha/beta-1 between cysteines 188 and 211.

Details

Redox score ?
79
PDB code
4mpw
Structure name
human beta-tryptase co-crystal structure with [(1,1,3,3- tetramethyldisiloxane-1,3-diyl)di-1-benzofuran-3,5-diyl]bis({4-[3- (aminomethyl)phenyl]piperidin-1-yl}methanone)
Structure deposition date
2013-09-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15661
Residue number A
188
Residue number B
211
Peptide name
Tryptase alpha/beta-1

Ligandability

Cysteine 188 of Tryptase alpha/beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 211 of Tryptase alpha/beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tryptase alpha/beta-1 between cysteines 59 and 75 (42 and 58 respectively in this structure).

Details

Redox score ?
77
PDB code
6o1f
Structure name
complex between soybean trypsin inhibitor beta1-tryptase and a humanized fab
Structure deposition date
2019-02-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
102
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15661
Residue number A
59
Residue number B
75
Peptide name
Tryptase alpha/beta-1

Ligandability

Cysteine 59 of Tryptase alpha/beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of Tryptase alpha/beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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