ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Ephrin-B3

Intramolecular
Cysteine 92 and cysteine 156
Cysteine 62 and cysteine 104
A redox-regulated disulphide may form within Ephrin-B3 between cysteines 92 and 156.

Details

Redox score ?
84
PDB code
4bkf
Structure name
crystal structure of the human epha4 ectodomain in complex with human ephrinb3
Structure deposition date
2013-04-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15768
Residue number A
92
Residue number B
156
Peptide name
Ephrin-B3

Ligandability

Cysteine 92 of Ephrin-B3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 156 of Ephrin-B3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ephrin-B3 between cysteines 62 and 104.

Details

Redox score ?
82
PDB code
4bkf
Structure name
crystal structure of the human epha4 ectodomain in complex with human ephrinb3
Structure deposition date
2013-04-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15768
Residue number A
62
Residue number B
104
Peptide name
Ephrin-B3

Ligandability

Cysteine 62 of Ephrin-B3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Ephrin-B3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: