a tool for identifying drug-targetable redox-active disulphides

Ras-related protein Rab-30

Intramolecular

Cysteine 93 and cysteine 99 L

A redox-regulated disulphide may form within Ras-related protein Rab-30 between cysteines 93 and 99 (92 and 98 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

52

PDB code

Structure name

crystal structure of rab30 in complex with a gtp analogue

Structure deposition date

2005-11-01

Thiol separation (Å)

8

Half-sphere exposure sum ?

49

Minimum pK_a ?

9

% buried

25

Peptide accession

Residue number A

93

Residue number B

99

Peptide name

Ras-related protein Rab-30

Ligandability

Cysteine 93 of Ras-related protein Rab-30

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 99 of Ras-related protein Rab-30

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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