ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Striated muscle preferentially expressed protein kinase

Intramolecular
Cysteine 942 and cysteine 953
Cysteine 925 and cysteine 942
A redox-regulated disulphide may form within Striated muscle preferentially expressed protein kinase between cysteines 942 and 953 (93 and 104 respectively in this structure).

Details

Redox score ?
61
PDB code
1u2h
Structure name
x-ray structure of the n-terminally truncated human apep-1
Structure deposition date
2004-07-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
54
Peptide accession
Q15772
Residue number A
942
Residue number B
953
Peptide name
Striated muscle preferentially expressed protein kinase

Ligandability

Cysteine 942 of Striated muscle preferentially expressed protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 953 of Striated muscle preferentially expressed protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Striated muscle preferentially expressed protein kinase between cysteines 925 and 942 (76 and 93 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
1u2h
Structure name
x-ray structure of the n-terminally truncated human apep-1
Structure deposition date
2004-07-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
52
Peptide accession
Q15772
Residue number A
925
Residue number B
942
Peptide name
Striated muscle preferentially expressed protein kinase

Ligandability

Cysteine 925 of Striated muscle preferentially expressed protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 942 of Striated muscle preferentially expressed protein kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: