ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Neuronal acetylcholine receptor subunit alpha-2

Intramolecular
Cysteine 183 and cysteine 197
Cysteine 247 and cysteine 248
A redox-regulated disulphide may form within Neuronal acetylcholine receptor subunit alpha-2 between cysteines 183 and 197 (157 and 171 respectively in this structure).

Details

Redox score ?
81
PDB code
5fjv
Structure name
crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assembly
Structure deposition date
2015-10-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15822
Residue number A
183
Residue number B
197
Peptide name
Neuronal acetylcholine receptor subunit alpha-2

Ligandability

Cysteine 183 of Neuronal acetylcholine receptor subunit alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Neuronal acetylcholine receptor subunit alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuronal acetylcholine receptor subunit alpha-2 between cysteines 247 and 248 (221 and 222 respectively in this structure).

Details

Redox score ?
80
PDB code
5fjv
Structure name
crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assembly
Structure deposition date
2015-10-13
Thiol separation (Å)
3
Half-sphere exposure sum ?
62
Minimum pKa ?
8
% buried
98
Peptide accession
Q15822
Residue number A
247
Residue number B
248
Peptide name
Neuronal acetylcholine receptor subunit alpha-2

Ligandability

Cysteine 247 of Neuronal acetylcholine receptor subunit alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of Neuronal acetylcholine receptor subunit alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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