ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Serine/threonine-protein kinase STK11

Intramolecular
Cysteine 151 and cysteine 158
Cysteine 132 and cysteine 134
A redox-regulated disulphide may form within Serine/threonine-protein kinase STK11 between cysteines 151 and 158. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
2wtk
Structure name
structure of the heterotrimeric lkb1-stradalpha-mo25alpha complex
Structure deposition date
2009-09-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
50
Peptide accession
Q15831
Residue number A
151
Residue number B
158
Peptide name
Serine/threonine-protein kinase STK11

Ligandability

Cysteine 151 of Serine/threonine-protein kinase STK11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 158 of Serine/threonine-protein kinase STK11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine/threonine-protein kinase STK11 between cysteines 132 and 134. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
2wtk
Structure name
structure of the heterotrimeric lkb1-stradalpha-mo25alpha complex
Structure deposition date
2009-09-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
81
Peptide accession
Q15831
Residue number A
132
Residue number B
134
Peptide name
Serine/threonine-protein kinase STK11

Ligandability

Cysteine 132 of Serine/threonine-protein kinase STK11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 134 of Serine/threonine-protein kinase STK11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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