ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Rhodopsin kinase GRK1

Intramolecular
Cysteine 204 and cysteine 215
Cysteine 215 and cysteine 261
Cysteine 204 and cysteine 261
Cysteine 215 and cysteine 511
A redox-regulated disulphide may form within Rhodopsin kinase GRK1 between cysteines 204 and 215.

Details

Redox score ?
69
PDB code
3c4y
Structure name
crystal structure of apo form of g protein coupled receptor kinase 1 at 7
Structure deposition date
2008-01-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
9
% buried
84
Peptide accession
P28327
Residue number A
204
Residue number B
215
Peptide name
Rhodopsin kinase GRK1

Ligandability

Cysteine 204 of Rhodopsin kinase GRK1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 215 of Rhodopsin kinase GRK1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rhodopsin kinase GRK1 between cysteines 215 and 261.

Details

Redox score ?
64
PDB code
3c4x
Structure name
crystal structure of g protein coupled receptor kinase 1 bound to atp and magnesium chloride at 2
Structure deposition date
2008-01-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
9
% buried
92
Peptide accession
P28327
Residue number A
215
Residue number B
261
Peptide name
Rhodopsin kinase GRK1

Ligandability

Cysteine 215 of Rhodopsin kinase GRK1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 261 of Rhodopsin kinase GRK1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rhodopsin kinase GRK1 between cysteines 204 and 261. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
3qc9
Structure name
crystal structure of cross-linked bovine grk1 t8c/n480c double mutant complexed with adp and mg
Structure deposition date
2011-01-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
9
% buried
84
Peptide accession
P28327
Residue number A
204
Residue number B
261
Peptide name
Rhodopsin kinase GRK1

Ligandability

Cysteine 204 of Rhodopsin kinase GRK1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 261 of Rhodopsin kinase GRK1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rhodopsin kinase GRK1 between cysteines 215 and 511. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
3c4y
Structure name
crystal structure of apo form of g protein coupled receptor kinase 1 at 7
Structure deposition date
2008-01-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
88
Peptide accession
P28327
Residue number A
215
Residue number B
511
Peptide name
Rhodopsin kinase GRK1

Ligandability

Cysteine 215 of Rhodopsin kinase GRK1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 511 of Rhodopsin kinase GRK1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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