ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

ATP-sensitive inward rectifier potassium channel 8

Intramolecular
Cysteine 120 and cysteine 152
Cysteine 207 and cysteine 268
A redox-regulated disulphide may form within ATP-sensitive inward rectifier potassium channel 8 between cysteines 120 and 152.

Details

Redox score ?
84
PDB code
7mjo
Structure name
vascular katp channel: kir6
Structure deposition date
2021-04-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q63664
Residue number A
120
Residue number B
152
Peptide name
ATP-sensitive inward rectifier potassium channel 8

Ligandability

Cysteine 120 of ATP-sensitive inward rectifier potassium channel 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 152 of ATP-sensitive inward rectifier potassium channel 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-sensitive inward rectifier potassium channel 8 between cysteines 207 and 268.

Details

Redox score ?
75
PDB code
7mit
Structure name
vascular katp channel: kir6
Structure deposition date
2021-04-17
Thiol separation (Å)
3
Half-sphere exposure sum ?
69
Minimum pKa ?
8
% buried
79
Peptide accession
Q63664
Residue number A
207
Residue number B
268
Peptide name
ATP-sensitive inward rectifier potassium channel 8

Ligandability

Cysteine 207 of ATP-sensitive inward rectifier potassium channel 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 268 of ATP-sensitive inward rectifier potassium channel 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: