ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sodium channel protein type 9 subunit alpha

Intermolecular
Cysteine 895 and cysteine 55 of Sodium channel subunit beta-2
Cysteine 903 and cysteine 55 of Sodium channel subunit beta-2
Cysteine 1185 and cysteine 181 of Sodium channel subunit beta-1
Cysteine 897 and cysteine 55 of Sodium channel subunit beta-2
Intramolecular
Cysteine 897 and cysteine 903
Cysteine 1715 and cysteine 1730
Cysteine 935 and cysteine 944
Cysteine 1350 and cysteine 1370
Cysteine 315 and cysteine 330
Cysteine 324 and cysteine 330
More...
Cysteine 315 and cysteine 324
Cysteine 275 and cysteine 315
Cysteine 275 and cysteine 324
Cysteine 275 and cysteine 330
Cysteine 895 and cysteine 903
Cysteine 895 and cysteine 897
Cysteine 895 and cysteine 935
A redox-regulated disulphide may form between cysteine 895 of Sodium channel protein type 9 subunit alpha and cysteine 55 of Sodium channel subunit beta-2.

Details

Redox score ?
73
PDB code
7xmf
Structure name
cryo-em structure of human nav1
Structure deposition date
2022-04-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
9
% buried
42
Peptide A name
Sodium channel protein type 9 subunit alpha
Peptide B name
Sodium channel subunit beta-2
Peptide A accession
Q15858
Peptide B accession
O60939
Peptide A residue number
895
Peptide B residue number
55

Ligandability

Cysteine 895 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 55 of Sodium channel subunit beta-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 903 of Sodium channel protein type 9 subunit alpha and cysteine 55 of Sodium channel subunit beta-2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7xmg
Structure name
cryo-em structure of human nav1
Structure deposition date
2022-04-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide A name
Sodium channel protein type 9 subunit alpha
Peptide B name
Sodium channel subunit beta-2
Peptide A accession
Q15858
Peptide B accession
O60939
Peptide A residue number
903
Peptide B residue number
55

Ligandability

Cysteine 903 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 55 of Sodium channel subunit beta-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 1185 of Sodium channel protein type 9 subunit alpha and cysteine 181 of Sodium channel subunit beta-1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7xve
Structure name
human nav1
Structure deposition date
2022-05-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
51
Peptide A name
Sodium channel protein type 9 subunit alpha
Peptide B name
Sodium channel subunit beta-1
Peptide A accession
Q15858
Peptide B accession
Q07699
Peptide A residue number
1185
Peptide B residue number
181

Ligandability

Cysteine 1185 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 181 of Sodium channel subunit beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 897 of Sodium channel protein type 9 subunit alpha and cysteine 55 of Sodium channel subunit beta-2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7w9l
Structure name
cryo-em structure of human nav1
Structure deposition date
2021-12-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide A name
Sodium channel protein type 9 subunit alpha
Peptide B name
Sodium channel subunit beta-2
Peptide A accession
Q15858
Peptide B accession
O60939
Peptide A residue number
897
Peptide B residue number
55

Ligandability

Cysteine 897 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 55 of Sodium channel subunit beta-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 9 subunit alpha between cysteines 897 and 903.

Details

Redox score ?
86
PDB code
7w9k
Structure name
cryo-em structure of human nav1
Structure deposition date
2021-12-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15858
Residue number A
897
Residue number B
903
Peptide name
Sodium channel protein type 9 subunit alpha

Ligandability

Cysteine 897 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 903 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 9 subunit alpha between cysteines 1715 and 1730.

Details

Redox score ?
85
PDB code
7w9l
Structure name
cryo-em structure of human nav1
Structure deposition date
2021-12-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15858
Residue number A
1715
Residue number B
1730
Peptide name
Sodium channel protein type 9 subunit alpha

Ligandability

Cysteine 1715 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1730 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 9 subunit alpha between cysteines 935 and 944.

Details

Redox score ?
84
PDB code
7xm9
Structure name
cryo-em structure of human nav1
Structure deposition date
2022-04-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15858
Residue number A
935
Residue number B
944
Peptide name
Sodium channel protein type 9 subunit alpha

Ligandability

Cysteine 935 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 944 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 9 subunit alpha between cysteines 1350 and 1370.

Details

Redox score ?
83
PDB code
7xmf
Structure name
cryo-em structure of human nav1
Structure deposition date
2022-04-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15858
Residue number A
1350
Residue number B
1370
Peptide name
Sodium channel protein type 9 subunit alpha

Ligandability

Cysteine 1350 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1370 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 9 subunit alpha between cysteines 315 and 330.

Details

Redox score ?
78
PDB code
6j8g
Structure name
structure of human voltage-gated sodium channel nav1
Structure deposition date
2019-01-19
Thiol separation (Å)
3
Half-sphere exposure sum ?
70
Minimum pKa ?
7
% buried
66
Peptide accession
Q15858
Residue number A
315
Residue number B
330
Peptide name
Sodium channel protein type 9 subunit alpha

Ligandability

Cysteine 315 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 330 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 9 subunit alpha between cysteines 324 and 330.

Details

Redox score ?
71
PDB code
7w9l
Structure name
cryo-em structure of human nav1
Structure deposition date
2021-12-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15858
Residue number A
324
Residue number B
330
Peptide name
Sodium channel protein type 9 subunit alpha

Ligandability

Cysteine 324 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 330 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 9 subunit alpha between cysteines 315 and 324.

Details

Redox score ?
71
PDB code
7w9k
Structure name
cryo-em structure of human nav1
Structure deposition date
2021-12-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15858
Residue number A
315
Residue number B
324
Peptide name
Sodium channel protein type 9 subunit alpha

Ligandability

Cysteine 315 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 324 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 9 subunit alpha between cysteines 275 and 315.

Details

Redox score ?
63
PDB code
7xmg
Structure name
cryo-em structure of human nav1
Structure deposition date
2022-04-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
13
% buried
nan
Peptide accession
Q15858
Residue number A
275
Residue number B
315
Peptide name
Sodium channel protein type 9 subunit alpha

Ligandability

Cysteine 275 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 315 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 9 subunit alpha between cysteines 275 and 324.

Details

Redox score ?
60
PDB code
7xmg
Structure name
cryo-em structure of human nav1
Structure deposition date
2022-04-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
76
Minimum pKa ?
10
% buried
78
Peptide accession
Q15858
Residue number A
275
Residue number B
324
Peptide name
Sodium channel protein type 9 subunit alpha

Ligandability

Cysteine 275 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 324 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 9 subunit alpha between cysteines 275 and 330. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7w9t
Structure name
cryo-em structure of human nav1
Structure deposition date
2021-12-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15858
Residue number A
275
Residue number B
330
Peptide name
Sodium channel protein type 9 subunit alpha

Ligandability

Cysteine 275 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 330 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 9 subunit alpha between cysteines 895 and 903. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7xmf
Structure name
cryo-em structure of human nav1
Structure deposition date
2022-04-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
51
Minimum pKa ?
11
% buried
nan
Peptide accession
Q15858
Residue number A
895
Residue number B
903
Peptide name
Sodium channel protein type 9 subunit alpha

Ligandability

Cysteine 895 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 903 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 9 subunit alpha between cysteines 895 and 897. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7xm9
Structure name
cryo-em structure of human nav1
Structure deposition date
2022-04-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15858
Residue number A
895
Residue number B
897
Peptide name
Sodium channel protein type 9 subunit alpha

Ligandability

Cysteine 895 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 897 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 9 subunit alpha between cysteines 895 and 935. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
25
PDB code
7w9m
Structure name
cryo-em structure of human nav1
Structure deposition date
2021-12-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
15
% buried
nan
Peptide accession
Q15858
Residue number A
895
Residue number B
935
Peptide name
Sodium channel protein type 9 subunit alpha

Ligandability

Cysteine 895 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 935 of Sodium channel protein type 9 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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