ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Voltage-dependent R-type calcium channel subunit alpha-1E

Intramolecular
Cysteine 1318 and cysteine 1329
Cysteine 1678 and cysteine 1694
Cysteine 251 and cysteine 273
Cysteine 268 and cysteine 279
Cysteine 268 and cysteine 273
Cysteine 251 and cysteine 268
Cysteine 273 and cysteine 279
Cysteine 251 and cysteine 279
Cysteine 1437 and cysteine 1446
A redox-regulated disulphide may form within Voltage-dependent R-type calcium channel subunit alpha-1E between cysteines 1318 and 1329.

Details

Redox score ?
87
PDB code
7xlq
Structure name
structure of human r-type voltage-gated cav2
Structure deposition date
2022-04-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15878
Residue number A
1318
Residue number B
1329
Peptide name
Voltage-dependent R-type calcium channel subunit alpha-1E

Ligandability

Cysteine 1318 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1329 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent R-type calcium channel subunit alpha-1E between cysteines 1678 and 1694.

Details

Redox score ?
86
PDB code
8epm
Structure name
calcium channel mutation
Structure deposition date
2022-10-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15878
Residue number A
1678
Residue number B
1694
Peptide name
Voltage-dependent R-type calcium channel subunit alpha-1E

Ligandability

Cysteine 1678 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1694 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent R-type calcium channel subunit alpha-1E between cysteines 251 and 273.

Details

Redox score ?
85
PDB code
7xlq
Structure name
structure of human r-type voltage-gated cav2
Structure deposition date
2022-04-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15878
Residue number A
251
Residue number B
273
Peptide name
Voltage-dependent R-type calcium channel subunit alpha-1E

Ligandability

Cysteine 251 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 273 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent R-type calcium channel subunit alpha-1E between cysteines 268 and 279.

Details

Redox score ?
82
PDB code
7xlq
Structure name
structure of human r-type voltage-gated cav2
Structure deposition date
2022-04-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15878
Residue number A
268
Residue number B
279
Peptide name
Voltage-dependent R-type calcium channel subunit alpha-1E

Ligandability

Cysteine 268 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent R-type calcium channel subunit alpha-1E between cysteines 268 and 273.

Details

Redox score ?
76
PDB code
8epl
Structure name
calcium channel
Structure deposition date
2022-10-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15878
Residue number A
268
Residue number B
273
Peptide name
Voltage-dependent R-type calcium channel subunit alpha-1E

Ligandability

Cysteine 268 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 273 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent R-type calcium channel subunit alpha-1E between cysteines 251 and 268.

Details

Redox score ?
72
PDB code
8epl
Structure name
calcium channel
Structure deposition date
2022-10-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15878
Residue number A
251
Residue number B
268
Peptide name
Voltage-dependent R-type calcium channel subunit alpha-1E

Ligandability

Cysteine 251 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 268 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent R-type calcium channel subunit alpha-1E between cysteines 273 and 279.

Details

Redox score ?
70
PDB code
8epm
Structure name
calcium channel mutation
Structure deposition date
2022-10-06
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15878
Residue number A
273
Residue number B
279
Peptide name
Voltage-dependent R-type calcium channel subunit alpha-1E

Ligandability

Cysteine 273 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent R-type calcium channel subunit alpha-1E between cysteines 251 and 279.

Details

Redox score ?
63
PDB code
8epm
Structure name
calcium channel mutation
Structure deposition date
2022-10-06
Thiol separation (Å)
6
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q15878
Residue number A
251
Residue number B
279
Peptide name
Voltage-dependent R-type calcium channel subunit alpha-1E

Ligandability

Cysteine 251 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent R-type calcium channel subunit alpha-1E between cysteines 1437 and 1446. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7xlq
Structure name
structure of human r-type voltage-gated cav2
Structure deposition date
2022-04-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
47
Minimum pKa ?
10
% buried
41
Peptide accession
Q15878
Residue number A
1437
Residue number B
1446
Peptide name
Voltage-dependent R-type calcium channel subunit alpha-1E

Ligandability

Cysteine 1437 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1446 of Voltage-dependent R-type calcium channel subunit alpha-1E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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