a tool for identifying drug-targetable redox-active disulphides

V-type proton ATPase subunit S1

Intramolecular

Cysteine 371 and cysteine 418

A redox-regulated disulphide may form within V-type proton ATPase subunit S1 between cysteines 371 and 418.

Details

Redox score ?

80

PDB code

Structure name

human v-atpase in state 2 with sidk and adp

Structure deposition date

2020-04-20

Thiol separation (Å)

2

Half-sphere exposure sum ?

72

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

371

Residue number B

418

Peptide name

V-type proton ATPase subunit S1

Ligandability

Cysteine 371 of V-type proton ATPase subunit S1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 418 of V-type proton ATPase subunit S1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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