ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Septin-7

Intramolecular
Cysteine 160 and cysteine 161
Cysteine 204 and cysteine 280
A redox-regulated disulphide may form within Septin-7 between cysteines 160 and 161 (141 and 142 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2qag
Structure name
crystal structure of human septin trimer 2/6/7
Structure deposition date
2007-06-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
82
Minimum pKa ?
10
% buried
57
Peptide accession
Q16181
Residue number A
160
Residue number B
161
Peptide name
Septin-7

Ligandability

Cysteine 160 of Septin-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 161 of Septin-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Septin-7 between cysteines 204 and 280 (185 and 261 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
3t5d
Structure name
crystal structure of septin 7 in complex with gdp
Structure deposition date
2011-07-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
86
Peptide accession
Q16181
Residue number A
204
Residue number B
280
Peptide name
Septin-7

Ligandability

Cysteine 204 of Septin-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of Septin-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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