ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cyclic nucleotide-gated cation channel alpha-3

Intramolecular
Cysteine 188 and cysteine 319
Cysteine 191 and cysteine 319
Cysteine 188 and cysteine 191
A redox-regulated disulphide may form within Cyclic nucleotide-gated cation channel alpha-3 between cysteines 188 and 319.

Details

Redox score ?
67
PDB code
7rhs
Structure name
cryo-em structure of apo-state of human cnga3/cngb3 channel
Structure deposition date
2021-07-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
9
% buried
91
Peptide accession
Q16281
Residue number A
188
Residue number B
319
Peptide name
Cyclic nucleotide-gated cation channel alpha-3

Ligandability

Cysteine 188 of Cyclic nucleotide-gated cation channel alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 319 of Cyclic nucleotide-gated cation channel alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cyclic nucleotide-gated cation channel alpha-3 between cysteines 191 and 319. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
7rhs
Structure name
cryo-em structure of apo-state of human cnga3/cngb3 channel
Structure deposition date
2021-07-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
84
Peptide accession
Q16281
Residue number A
191
Residue number B
319
Peptide name
Cyclic nucleotide-gated cation channel alpha-3

Ligandability

Cysteine 191 of Cyclic nucleotide-gated cation channel alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 319 of Cyclic nucleotide-gated cation channel alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cyclic nucleotide-gated cation channel alpha-3 between cysteines 188 and 191. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7rhs
Structure name
cryo-em structure of apo-state of human cnga3/cngb3 channel
Structure deposition date
2021-07-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
9
% buried
84
Peptide accession
Q16281
Residue number A
188
Residue number B
191
Peptide name
Cyclic nucleotide-gated cation channel alpha-3

Ligandability

Cysteine 188 of Cyclic nucleotide-gated cation channel alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 191 of Cyclic nucleotide-gated cation channel alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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