ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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NT-3 growth factor receptor

Intramolecular
Cysteine 320 and cysteine 362
Cysteine 557 and cysteine 607
A redox-regulated disulphide may form within NT-3 growth factor receptor between cysteines 320 and 362.

Details

Redox score ?
84
PDB code
1wwc
Structure name
nt3 binding domain of human trkc receptor
Structure deposition date
1999-04-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16288
Residue number A
320
Residue number B
362
Peptide name
NT-3 growth factor receptor

Ligandability

Cysteine 320 of NT-3 growth factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 362 of NT-3 growth factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NT-3 growth factor receptor between cysteines 557 and 607. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
3v5q
Structure name
discovery of a selective trk inhibitor with efficacy in rodent cancer tumor models
Structure deposition date
2011-12-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
42
Peptide accession
Q16288
Residue number A
557
Residue number B
607
Peptide name
NT-3 growth factor receptor

Ligandability

Cysteine 557 of NT-3 growth factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 607 of NT-3 growth factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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