ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Solute carrier family 15 member 2

Intramolecular
Cysteine 211 and cysteine 216
Cysteine 388 and cysteine 686
Cysteine 388 and cysteine 680
A redox-regulated disulphide may form within Solute carrier family 15 member 2 between cysteines 211 and 216.

Details

Redox score ?
73
PDB code
7pmy
Structure name
hspept2 bound to ala-phe in the inward facing partially occluded conformation
Structure deposition date
2021-09-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
48
Minimum pKa ?
8
% buried
10
Peptide accession
Q16348
Residue number A
211
Residue number B
216
Peptide name
Solute carrier family 15 member 2

Ligandability

Cysteine 211 of Solute carrier family 15 member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Solute carrier family 15 member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 15 member 2 between cysteines 388 and 686. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7pmy
Structure name
hspept2 bound to ala-phe in the inward facing partially occluded conformation
Structure deposition date
2021-09-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
45
Peptide accession
Q16348
Residue number A
388
Residue number B
686
Peptide name
Solute carrier family 15 member 2

Ligandability

Cysteine 388 of Solute carrier family 15 member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 686 of Solute carrier family 15 member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 15 member 2 between cysteines 388 and 680. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7pmy
Structure name
hspept2 bound to ala-phe in the inward facing partially occluded conformation
Structure deposition date
2021-09-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
9
% buried
25
Peptide accession
Q16348
Residue number A
388
Residue number B
680
Peptide name
Solute carrier family 15 member 2

Ligandability

Cysteine 388 of Solute carrier family 15 member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 680 of Solute carrier family 15 member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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