ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Glutamate receptor ionotropic, kainate 5

Intermolecular
Cysteine 83 and cysteine 347 of Glutamate receptor ionotropic, kainate 2
Cysteine 83 and cysteine 96 of Glutamate receptor ionotropic, kainate 2
Intramolecular
Cysteine 36 and cysteine 292
Cysteine 83 and cysteine 334
Cysteine 165 and cysteine 170
A redox-regulated disulphide may form between cysteine 83 of Glutamate receptor ionotropic, kainate 5 and cysteine 347 of Glutamate receptor ionotropic, kainate 2 (64 and 316 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3qlv
Structure name
crystal structure of the gluk2/gluk5 (glur6/ka2) atd tetramer assembly
Structure deposition date
2011-02-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glutamate receptor ionotropic, kainate 5
Peptide B name
Glutamate receptor ionotropic, kainate 2
Peptide A accession
Q63273
Peptide B accession
P42260
Peptide A residue number
83
Peptide B residue number
347

Ligandability

Cysteine 83 of Glutamate receptor ionotropic, kainate 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 347 of Glutamate receptor ionotropic, kainate 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 83 of Glutamate receptor ionotropic, kainate 5 and cysteine 96 of Glutamate receptor ionotropic, kainate 2 (64 and 65 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
3qlu
Structure name
crystal structure of the gluk2/gluk5 (glur6/ka2) atd dimer assembly
Structure deposition date
2011-02-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glutamate receptor ionotropic, kainate 5
Peptide B name
Glutamate receptor ionotropic, kainate 2
Peptide A accession
Q63273
Peptide B accession
P42260
Peptide A residue number
83
Peptide B residue number
96

Ligandability

Cysteine 83 of Glutamate receptor ionotropic, kainate 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Glutamate receptor ionotropic, kainate 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glutamate receptor ionotropic, kainate 5 between cysteines 36 and 292 (17 and 273 respectively in this structure).

Details

Redox score ?
87
PDB code
3om1
Structure name
crystal structure of the gluk5 (ka2) atd dimer at 1
Structure deposition date
2010-08-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q63273
Residue number A
36
Residue number B
292
Peptide name
Glutamate receptor ionotropic, kainate 5

Ligandability

Cysteine 36 of Glutamate receptor ionotropic, kainate 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 292 of Glutamate receptor ionotropic, kainate 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glutamate receptor ionotropic, kainate 5 between cysteines 83 and 334 (64 and 315 respectively in this structure).

Details

Redox score ?
84
PDB code
3qlv
Structure name
crystal structure of the gluk2/gluk5 (glur6/ka2) atd tetramer assembly
Structure deposition date
2011-02-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q63273
Residue number A
83
Residue number B
334
Peptide name
Glutamate receptor ionotropic, kainate 5

Ligandability

Cysteine 83 of Glutamate receptor ionotropic, kainate 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 334 of Glutamate receptor ionotropic, kainate 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glutamate receptor ionotropic, kainate 5 between cysteines 165 and 170 (146 and 151 respectively in this structure).

Details

Redox score ?
79
PDB code
3qlv
Structure name
crystal structure of the gluk2/gluk5 (glur6/ka2) atd tetramer assembly
Structure deposition date
2011-02-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q63273
Residue number A
165
Residue number B
170
Peptide name
Glutamate receptor ionotropic, kainate 5

Ligandability

Cysteine 165 of Glutamate receptor ionotropic, kainate 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 170 of Glutamate receptor ionotropic, kainate 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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