ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Serine/threonine-protein kinase N2

Intramolecular
Cysteine 704 and cysteine 804
Cysteine 659 and cysteine 660
Cysteine 659 and cysteine 734
Cysteine 804 and cysteine 818
Cysteine 726 and cysteine 734
A redox-regulated disulphide may form within Serine/threonine-protein kinase N2 between cysteines 704 and 804. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
4crs
Structure name
human protein kinase n2 (pkn2, prkcl2) in complex with atpgammas
Structure deposition date
2014-02-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
12
% buried
80
Peptide accession
Q16513
Residue number A
704
Residue number B
804
Peptide name
Serine/threonine-protein kinase N2

Ligandability

Cysteine 704 of Serine/threonine-protein kinase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 804 of Serine/threonine-protein kinase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine/threonine-protein kinase N2 between cysteines 659 and 660. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
4crs
Structure name
human protein kinase n2 (pkn2, prkcl2) in complex with atpgammas
Structure deposition date
2014-02-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
76
Peptide accession
Q16513
Residue number A
659
Residue number B
660
Peptide name
Serine/threonine-protein kinase N2

Ligandability

Cysteine 659 of Serine/threonine-protein kinase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 660 of Serine/threonine-protein kinase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine/threonine-protein kinase N2 between cysteines 659 and 734. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
4crs
Structure name
human protein kinase n2 (pkn2, prkcl2) in complex with atpgammas
Structure deposition date
2014-02-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
90
Peptide accession
Q16513
Residue number A
659
Residue number B
734
Peptide name
Serine/threonine-protein kinase N2

Ligandability

Cysteine 659 of Serine/threonine-protein kinase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 734 of Serine/threonine-protein kinase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine/threonine-protein kinase N2 between cysteines 804 and 818 (296 and 310 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6ccy
Structure name
crystal structure of akt1 in complex with a selective inhibitor
Structure deposition date
2018-02-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
84
Peptide accession
Q16513
Residue number A
804
Residue number B
818
Peptide name
Serine/threonine-protein kinase N2

Ligandability

Cysteine 804 of Serine/threonine-protein kinase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 818 of Serine/threonine-protein kinase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine/threonine-protein kinase N2 between cysteines 726 and 734. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
4crs
Structure name
human protein kinase n2 (pkn2, prkcl2) in complex with atpgammas
Structure deposition date
2014-02-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
86
Peptide accession
Q16513
Residue number A
726
Residue number B
734
Peptide name
Serine/threonine-protein kinase N2

Ligandability

Cysteine 726 of Serine/threonine-protein kinase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 734 of Serine/threonine-protein kinase N2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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