Acid-sensing ion channel 2
Intramolecular
Cysteine 289 and cysteine 364
Cysteine 307 and cysteine 360
Cysteine 320 and cysteine 342
Cysteine 322 and cysteine 334
Cysteine 311 and cysteine 358
Cysteine 92 and cysteine 193
Cysteine 171 and cysteine 178
Cysteine 358 and cysteine 360
Cysteine 320 and cysteine 322
Cysteine 320 and cysteine 334
More...Cysteine 307 and cysteine 358
Cysteine 307 and cysteine 311
Cysteine 334 and cysteine 342
Cysteine 322 and cysteine 342
Cysteine 311 and cysteine 360
6l6p C 289 C 364
A redox-regulated disulphide may form within Acid-sensing ion channel 2 between cysteines 289 and 364.
Details
Redox score ?
86
PDB code
6l6p
Structure name
hasic2a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16515
Residue number A
289
Residue number B
364
Peptide name
Acid-sensing ion channel 2
Ligandability
Cysteine 289 of Acid-sensing ion channel 2
Cysteine 364 of Acid-sensing ion channel 2
6l6p B 307 B 360
A redox-regulated disulphide may form within Acid-sensing ion channel 2 between cysteines 307 and 360.
Details
Redox score ?
85
PDB code
6l6p
Structure name
hasic2a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16515
Residue number A
307
Residue number B
360
Peptide name
Acid-sensing ion channel 2
Ligandability
Cysteine 307 of Acid-sensing ion channel 2
Cysteine 360 of Acid-sensing ion channel 2
6l6p A 320 A 342
A redox-regulated disulphide may form within Acid-sensing ion channel 2 between cysteines 320 and 342.
Details
Redox score ?
84
PDB code
6l6p
Structure name
hasic2a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16515
Residue number A
320
Residue number B
342
Peptide name
Acid-sensing ion channel 2
Ligandability
Cysteine 320 of Acid-sensing ion channel 2
Cysteine 342 of Acid-sensing ion channel 2
6l6p A 322 A 334
A redox-regulated disulphide may form within Acid-sensing ion channel 2 between cysteines 322 and 334.
Details
Redox score ?
83
PDB code
6l6p
Structure name
hasic2a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16515
Residue number A
322
Residue number B
334
Peptide name
Acid-sensing ion channel 2
Ligandability
Cysteine 322 of Acid-sensing ion channel 2
Cysteine 334 of Acid-sensing ion channel 2
6l6p B 311 B 358
A redox-regulated disulphide may form within Acid-sensing ion channel 2 between cysteines 311 and 358.
Details
Redox score ?
83
PDB code
6l6p
Structure name
hasic2a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16515
Residue number A
311
Residue number B
358
Peptide name
Acid-sensing ion channel 2
Ligandability
Cysteine 311 of Acid-sensing ion channel 2
Cysteine 358 of Acid-sensing ion channel 2
6l6p B 92 B 193
A redox-regulated disulphide may form within Acid-sensing ion channel 2 between cysteines 92 and 193.
Details
Redox score ?
80
PDB code
6l6p
Structure name
hasic2a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16515
Residue number A
92
Residue number B
193
Peptide name
Acid-sensing ion channel 2
Ligandability
Cysteine 92 of Acid-sensing ion channel 2
Cysteine 193 of Acid-sensing ion channel 2
6l6p B 171 B 178
A redox-regulated disulphide may form within Acid-sensing ion channel 2 between cysteines 171 and 178.
Details
Redox score ?
80
PDB code
6l6p
Structure name
hasic2a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
8
% buried
60
Peptide accession
Q16515
Residue number A
171
Residue number B
178
Peptide name
Acid-sensing ion channel 2
Ligandability
Cysteine 171 of Acid-sensing ion channel 2
Cysteine 178 of Acid-sensing ion channel 2
6l6p B 358 B 360
A redox-regulated disulphide may form within Acid-sensing ion channel 2 between cysteines 358 and 360.
Details
Redox score ?
73
PDB code
6l6p
Structure name
hasic2a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16515
Residue number A
358
Residue number B
360
Peptide name
Acid-sensing ion channel 2
Ligandability
Cysteine 358 of Acid-sensing ion channel 2
Cysteine 360 of Acid-sensing ion channel 2
6l6p A 320 A 322
A redox-regulated disulphide may form within Acid-sensing ion channel 2 between cysteines 320 and 322.
Details
Redox score ?
65
PDB code
6l6p
Structure name
hasic2a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
5
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16515
Residue number A
320
Residue number B
322
Peptide name
Acid-sensing ion channel 2
Ligandability
Cysteine 320 of Acid-sensing ion channel 2
Cysteine 322 of Acid-sensing ion channel 2
6l6p B 320 B 334
A redox-regulated disulphide may form within Acid-sensing ion channel 2 between cysteines 320 and 334.
Details
Redox score ?
65
PDB code
6l6p
Structure name
hasic2a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16515
Residue number A
320
Residue number B
334
Peptide name
Acid-sensing ion channel 2
Ligandability
Cysteine 320 of Acid-sensing ion channel 2
Cysteine 334 of Acid-sensing ion channel 2
6l6p B 307 B 358
A redox-regulated disulphide may form within Acid-sensing ion channel 2 between cysteines 307 and 358.
Details
Redox score ?
63
PDB code
6l6p
Structure name
hasic2a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16515
Residue number A
307
Residue number B
358
Peptide name
Acid-sensing ion channel 2
Ligandability
Cysteine 307 of Acid-sensing ion channel 2
Cysteine 358 of Acid-sensing ion channel 2
6l6p C 307 C 311
A redox-regulated disulphide may form within Acid-sensing ion channel 2 between cysteines 307 and 311.
Details
Redox score ?
62
PDB code
6l6p
Structure name
hasic2a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
nan
Peptide accession
Q16515
Residue number A
307
Residue number B
311
Peptide name
Acid-sensing ion channel 2
Ligandability
Cysteine 307 of Acid-sensing ion channel 2
Cysteine 311 of Acid-sensing ion channel 2
6l6p B 334 B 342
A redox-regulated disulphide may form within Acid-sensing ion channel 2 between cysteines 334 and 342.
Details
Redox score ?
61
PDB code
6l6p
Structure name
hasic2a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16515
Residue number A
334
Residue number B
342
Peptide name
Acid-sensing ion channel 2
Ligandability
Cysteine 334 of Acid-sensing ion channel 2
Cysteine 342 of Acid-sensing ion channel 2
6l6p A 322 A 342
A redox-regulated disulphide may form within Acid-sensing ion channel 2 between cysteines 322 and 342. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
60
PDB code
6l6p
Structure name
hasic2a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16515
Residue number A
322
Residue number B
342
Peptide name
Acid-sensing ion channel 2
Ligandability
Cysteine 322 of Acid-sensing ion channel 2
Cysteine 342 of Acid-sensing ion channel 2
6l6p C 311 C 360
A redox-regulated disulphide may form within Acid-sensing ion channel 2 between cysteines 311 and 360. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
6l6p
Structure name
hasic2a co-crystallized with mamb-1
Structure deposition date
2019-10-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
51
Minimum pKa ?
10
% buried
nan
Peptide accession
Q16515
Residue number A
311
Residue number B
360
Peptide name
Acid-sensing ion channel 2
Ligandability
Cysteine 311 of Acid-sensing ion channel 2
Cysteine 360 of Acid-sensing ion channel 2
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