DNA damage-binding protein 1
Intramolecular
Cysteine 18 and cysteine 313
Cysteine 540 and cysteine 604
Cysteine 173 and cysteine 179
Cysteine 260 and cysteine 313
Cysteine 363 and cysteine 1008
Cysteine 725 and cysteine 732
Cysteine 725 and cysteine 1008
Cysteine 460 and cysteine 680
Cysteine 18 and cysteine 260
Cysteine 460 and cysteine 503
More...Cysteine 725 and cysteine 819
Cysteine 363 and cysteine 725
Cysteine 363 and cysteine 378 L
Cysteine 378 and cysteine 725 L
Cysteine 378 and cysteine 1008 L
Cysteine 540 and cysteine 556
Cysteine 652 and cysteine 680
4ci2 A 18 A 313
A redox-regulated disulphide may form within DNA damage-binding protein 1 between cysteines 18 and 313.
Details
Redox score ?
70
PDB code
4ci2
Structure name
structure of the ddb1-crbn e3 ubiquitin ligase bound to lenalidomide
Structure deposition date
2013-12-05
Thiol separation (Å)
3
Half-sphere exposure sum ?
89
Minimum pKa ?
8
% buried
100
Peptide accession
Q16531
Residue number A
18
Residue number B
313
Peptide name
DNA damage-binding protein 1
Ligandability
Cysteine 18 of DNA damage-binding protein 1
Cysteine 313 of DNA damage-binding protein 1
6dsz B 540 B 604
A redox-regulated disulphide may form within DNA damage-binding protein 1 between cysteines 540 and 604. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
6dsz
Structure name
crystal structure of ddb1 in complex with det1- and ddb1-associated protein 1 (dda1)
Structure deposition date
2018-06-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
90
Minimum pKa ?
12
% buried
100
Peptide accession
Q16531
Residue number A
540
Residue number B
604
Peptide name
DNA damage-binding protein 1
Ligandability
Cysteine 540 of DNA damage-binding protein 1
Cysteine 604 of DNA damage-binding protein 1
3i7l A 173 A 179
A redox-regulated disulphide may form within DNA damage-binding protein 1 between cysteines 173 and 179. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
3i7l
Structure name
crystal structure of ddb1 in complex with the h-box motif of ddb2
Structure deposition date
2009-07-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
76
Peptide accession
Q16531
Residue number A
173
Residue number B
179
Peptide name
DNA damage-binding protein 1
Ligandability
Cysteine 173 of DNA damage-binding protein 1
Cysteine 179 of DNA damage-binding protein 1
3i89 A 260 A 313
A redox-regulated disulphide may form within DNA damage-binding protein 1 between cysteines 260 and 313. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
3i89
Structure name
crystal structure of ddb1 in complex with the h-box motif of wdr22
Structure deposition date
2009-07-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
13
% buried
nan
Peptide accession
Q16531
Residue number A
260
Residue number B
313
Peptide name
DNA damage-binding protein 1
Ligandability
Cysteine 260 of DNA damage-binding protein 1
Cysteine 313 of DNA damage-binding protein 1
6xk9 B 363 B 1008
A redox-regulated disulphide may form within DNA damage-binding protein 1 between cysteines 363 and 1008. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
6xk9
Structure name
cereblon in complex with ddb1, cc-90009, and gspt1
Structure deposition date
2020-06-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
92
Peptide accession
Q16531
Residue number A
363
Residue number B
1008
Peptide name
DNA damage-binding protein 1
Ligandability
Cysteine 363 of DNA damage-binding protein 1
Cysteine 1008 of DNA damage-binding protein 1
6bn8 A 725 A 732
A redox-regulated disulphide may form within DNA damage-binding protein 1 between cysteines 725 and 732. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
6bn8
Structure name
crystal structure of ddb1-crbn-brd4(bd1) complex bound to dbet55 protac
Structure deposition date
2017-11-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
86
Peptide accession
Q16531
Residue number A
725
Residue number B
732
Peptide name
DNA damage-binding protein 1
Ligandability
Cysteine 725 of DNA damage-binding protein 1
Cysteine 732 of DNA damage-binding protein 1
6sj7 B 725 B 1008
A redox-regulated disulphide may form within DNA damage-binding protein 1 between cysteines 725 and 1008. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
6sj7
Structure name
structure of the human ddb1-dda1-dcaf15 e3 ubiquitin ligase bound to rbm39 and indisulam
Structure deposition date
2019-08-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
94
Peptide accession
Q16531
Residue number A
725
Residue number B
1008
Peptide name
DNA damage-binding protein 1
Ligandability
Cysteine 725 of DNA damage-binding protein 1
Cysteine 1008 of DNA damage-binding protein 1
4e5z A 460 A 680
A redox-regulated disulphide may form within DNA damage-binding protein 1 between cysteines 460 and 680. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
4e5z
Structure name
damaged dna induced uv-damaged dna-binding protein (uv-ddb) dimerization and its roles in chromatinized dna repair
Structure deposition date
2012-03-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
100
Peptide accession
Q16531
Residue number A
460
Residue number B
680
Peptide name
DNA damage-binding protein 1
Ligandability
Cysteine 460 of DNA damage-binding protein 1
Cysteine 680 of DNA damage-binding protein 1
3i89 A 18 A 260
A redox-regulated disulphide may form within DNA damage-binding protein 1 between cysteines 18 and 260. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
3i89
Structure name
crystal structure of ddb1 in complex with the h-box motif of wdr22
Structure deposition date
2009-07-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
13
% buried
nan
Peptide accession
Q16531
Residue number A
18
Residue number B
260
Peptide name
DNA damage-binding protein 1
Ligandability
Cysteine 18 of DNA damage-binding protein 1
Cysteine 260 of DNA damage-binding protein 1
3i8e B 460 B 503
A redox-regulated disulphide may form within DNA damage-binding protein 1 between cysteines 460 and 503. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
3i8e
Structure name
crystal structure of ddb1 in complex with the h-box motif of wdr42a
Structure deposition date
2009-07-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
98
Peptide accession
Q16531
Residue number A
460
Residue number B
503
Peptide name
DNA damage-binding protein 1
Ligandability
Cysteine 460 of DNA damage-binding protein 1
Cysteine 503 of DNA damage-binding protein 1
6td3 A 725 A 819
A redox-regulated disulphide may form within DNA damage-binding protein 1 between cysteines 725 and 819. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
6td3
Structure name
structure of ddb1 bound to cr8-engaged cdk12-cyclink
Structure deposition date
2019-11-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
89
Peptide accession
Q16531
Residue number A
725
Residue number B
819
Peptide name
DNA damage-binding protein 1
Ligandability
Cysteine 725 of DNA damage-binding protein 1
Cysteine 819 of DNA damage-binding protein 1
6bnb A 363 A 725
A redox-regulated disulphide may form within DNA damage-binding protein 1 between cysteines 363 and 725. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
6bnb
Structure name
crystal structure of ddb1-crbn-brd4(bd1) complex bound to dbet57 protac
Structure deposition date
2017-11-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
13
% buried
100
Peptide accession
Q16531
Residue number A
363
Residue number B
725
Peptide name
DNA damage-binding protein 1
Ligandability
Cysteine 363 of DNA damage-binding protein 1
Cysteine 725 of DNA damage-binding protein 1
4e5z A 363 A 378
A redox-regulated disulphide may form within DNA damage-binding protein 1 between cysteines 363 and 378. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
27
PDB code
4e5z
Structure name
damaged dna induced uv-damaged dna-binding protein (uv-ddb) dimerization and its roles in chromatinized dna repair
Structure deposition date
2012-03-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
89
Minimum pKa ?
12
% buried
100
Peptide accession
Q16531
Residue number A
363
Residue number B
378
Peptide name
DNA damage-binding protein 1
Ligandability
Cysteine 363 of DNA damage-binding protein 1
Cysteine 378 of DNA damage-binding protein 1
2hye A 378 A 725
A redox-regulated disulphide may form within DNA damage-binding protein 1 between cysteines 378 and 725. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
25
PDB code
2hye
Structure name
crystal structure of the ddb1-cul4a-rbx1-sv5v complex
Structure deposition date
2006-08-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
100
Peptide accession
Q16531
Residue number A
378
Residue number B
725
Peptide name
DNA damage-binding protein 1
Ligandability
Cysteine 378 of DNA damage-binding protein 1
Cysteine 725 of DNA damage-binding protein 1
4e54 A 378 A 1008
A redox-regulated disulphide may form within DNA damage-binding protein 1 between cysteines 378 and 1008. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
24
PDB code
4e54
Structure name
damaged dna induced uv-damaged dna-binding protein (uv-ddb) dimerization and its roles in chromatinized dna repair
Structure deposition date
2012-03-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
99
Peptide accession
Q16531
Residue number A
378
Residue number B
1008
Peptide name
DNA damage-binding protein 1
Ligandability
Cysteine 378 of DNA damage-binding protein 1
Cysteine 1008 of DNA damage-binding protein 1
4a0b A 540 A 556
A redox-regulated disulphide may form within DNA damage-binding protein 1 between cysteines 540 and 556. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
23
PDB code
4a0b
Structure name
structure of hsddb1-drddb2 bound to a 16 bp cpd-duplex (pyrimidine at d-1 position) at 3
Structure deposition date
2011-09-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
100
Peptide accession
Q16531
Residue number A
540
Residue number B
556
Peptide name
DNA damage-binding protein 1
Ligandability
Cysteine 540 of DNA damage-binding protein 1
Cysteine 556 of DNA damage-binding protein 1
3ei2 A 652 A 680
A redox-regulated disulphide may form within DNA damage-binding protein 1 between cysteines 652 and 680. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
22
PDB code
3ei2
Structure name
structure of hsddb1-drddb2 bound to a 16 bp abasic site containing dna-duplex
Structure deposition date
2008-09-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
100
Peptide accession
Q16531
Residue number A
652
Residue number B
680
Peptide name
DNA damage-binding protein 1
Ligandability
Cysteine 652 of DNA damage-binding protein 1
Cysteine 680 of DNA damage-binding protein 1
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