ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mitogen-activated protein kinase 14

Intermolecular
Cysteine 119 and cysteine 119
Intramolecular
Cysteine 119 and cysteine 162
A redox-regulated disulphide may form between two units of Mitogen-activated protein kinase 14 at cysteines 119 and 119.

Details

Redox score ?
87
PDB code
5eta
Structure name
structure of mapk14 with bound the kim domain of the toxoplasma protein gra24
Structure deposition date
2015-11-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide A name
Mitogen-activated protein kinase 14
Peptide B name
Mitogen-activated protein kinase 14
Peptide A accession
Q16539
Peptide B accession
Q16539
Peptide A residue number
119
Peptide B residue number
119

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mitogen-activated protein kinase 14 between cysteines 119 and 162. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
3heg
Structure name
p38 in complex with sorafenib
Structure deposition date
2009-05-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
14
Peptide accession
Q16539
Residue number A
119
Residue number B
162
Peptide name
Mitogen-activated protein kinase 14

Ligandability

Cysteine 119 of Mitogen-activated protein kinase 14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 162 of Mitogen-activated protein kinase 14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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