ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Hsp90 co-chaperone Cdc37

Intramolecular
Cysteine 54 and cysteine 57
Cysteine 57 and cysteine 64
A redox-regulated disulphide may form within Hsp90 co-chaperone Cdc37 between cysteines 54 and 57. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
2nca
Structure name
structural model for the n-terminal domain of human cdc37
Structure deposition date
2016-03-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
3
Peptide accession
Q16543
Residue number A
54
Residue number B
57
Peptide name
Hsp90 co-chaperone Cdc37

Ligandability

Cysteine 54 of Hsp90 co-chaperone Cdc37

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 57 of Hsp90 co-chaperone Cdc37

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hsp90 co-chaperone Cdc37 between cysteines 57 and 64. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2nca
Structure name
structural model for the n-terminal domain of human cdc37
Structure deposition date
2016-03-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
3
Peptide accession
Q16543
Residue number A
57
Residue number B
64
Peptide name
Hsp90 co-chaperone Cdc37

Ligandability

Cysteine 57 of Hsp90 co-chaperone Cdc37

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 64 of Hsp90 co-chaperone Cdc37

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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