ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Bcl-2-related protein A1

Intermolecular
Cysteine 4 and cysteine 4
Cysteine 55 and cysteine 25 of Phorbol-12-myristate-13-acetate-induced protein 1
A redox-regulated disulphide may form between two units of Bcl-2-related protein A1 at cysteines 4 and 4.

Details

Redox score ?
81
PDB code
6rjp
Structure name
bfl-1 in complex with alpha helical peptide
Structure deposition date
2019-04-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide A name
Bcl-2-related protein A1
Peptide B name
Bcl-2-related protein A1
Peptide A accession
Q16548
Peptide B accession
Q16548
Peptide A residue number
4
Peptide B residue number
4

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 55 of Bcl-2-related protein A1 and cysteine 25 of Phorbol-12-myristate-13-acetate-induced protein 1.

Details

Redox score ?
72
PDB code
3mqp
Structure name
crystal structure of human bfl-1 in complex with noxa bh3 peptide, northeast structural genomics consortium target hr2930
Structure deposition date
2010-04-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
42
Peptide A name
Bcl-2-related protein A1
Peptide B name
Phorbol-12-myristate-13-acetate-induced protein 1
Peptide A accession
Q16548
Peptide B accession
Q13794
Peptide A residue number
55
Peptide B residue number
25

Ligandability

Cysteine 55 of Bcl-2-related protein A1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 25 of Phorbol-12-myristate-13-acetate-induced protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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