ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dihydropyrimidinase-related protein 2

Intermolecular
Cysteine 323 and cysteine 323
Intramolecular
Cysteine 132 and cysteine 133
A redox-regulated disulphide may form between two units of Dihydropyrimidinase-related protein 2 at cysteines 323 and 323. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7u5k
Structure name
cryo-em structure of dpysl2
Structure deposition date
2022-03-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
100
Peptide A name
Dihydropyrimidinase-related protein 2
Peptide B name
Dihydropyrimidinase-related protein 2
Peptide A accession
O02675
Peptide B accession
O02675
Peptide A residue number
323
Peptide B residue number
323

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dihydropyrimidinase-related protein 2 between cysteines 132 and 133. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
5uqc
Structure name
crystal structure of mouse crmp2
Structure deposition date
2017-02-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
90
Minimum pKa ?
11
% buried
82
Peptide accession
O08553
Residue number A
132
Residue number B
133
Peptide name
Dihydropyrimidinase-related protein 2

Ligandability

Cysteine 132 of Dihydropyrimidinase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Dihydropyrimidinase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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