ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Cocaine- and amphetamine-regulated transcript protein

Intramolecular
Cysteine 102 and cysteine 115
Cysteine 82 and cysteine 100
Cysteine 88 and cysteine 108
Cysteine 102 and cysteine 108
Cysteine 82 and cysteine 115
Cysteine 88 and cysteine 102
Cysteine 88 and cysteine 115
Cysteine 108 and cysteine 115
Cysteine 82 and cysteine 102
Cysteine 82 and cysteine 88
More...
Cysteine 82 and cysteine 108
Cysteine 100 and cysteine 115
Cysteine 88 and cysteine 100
Cysteine 100 and cysteine 102
Cysteine 100 and cysteine 108
A redox-regulated disulphide may form within Cocaine- and amphetamine-regulated transcript protein between cysteines 102 and 115 (75 and 88 respectively in this structure).

Details

Redox score ?
87
PDB code
1hy9
Structure name
cocaine and amphetamine regulated transcript
Structure deposition date
2001-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16568
Residue number A
102
Residue number B
115
Peptide name
Cocaine- and amphetamine-regulated transcript protein

Ligandability

Cysteine 102 of Cocaine- and amphetamine-regulated transcript protein

Cysteine 115 of Cocaine- and amphetamine-regulated transcript protein

A redox-regulated disulphide may form within Cocaine- and amphetamine-regulated transcript protein between cysteines 82 and 100 (55 and 73 respectively in this structure).

Details

Redox score ?
86
PDB code
1hy9
Structure name
cocaine and amphetamine regulated transcript
Structure deposition date
2001-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16568
Residue number A
82
Residue number B
100
Peptide name
Cocaine- and amphetamine-regulated transcript protein

Ligandability

Cysteine 82 of Cocaine- and amphetamine-regulated transcript protein

Cysteine 100 of Cocaine- and amphetamine-regulated transcript protein

A redox-regulated disulphide may form within Cocaine- and amphetamine-regulated transcript protein between cysteines 88 and 108 (61 and 81 respectively in this structure).

Details

Redox score ?
84
PDB code
1hy9
Structure name
cocaine and amphetamine regulated transcript
Structure deposition date
2001-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16568
Residue number A
88
Residue number B
108
Peptide name
Cocaine- and amphetamine-regulated transcript protein

Ligandability

Cysteine 88 of Cocaine- and amphetamine-regulated transcript protein

Cysteine 108 of Cocaine- and amphetamine-regulated transcript protein

A redox-regulated disulphide may form within Cocaine- and amphetamine-regulated transcript protein between cysteines 102 and 108 (75 and 81 respectively in this structure).

Details

Redox score ?
79
PDB code
1hy9
Structure name
cocaine and amphetamine regulated transcript
Structure deposition date
2001-01-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16568
Residue number A
102
Residue number B
108
Peptide name
Cocaine- and amphetamine-regulated transcript protein

Ligandability

Cysteine 102 of Cocaine- and amphetamine-regulated transcript protein

Cysteine 108 of Cocaine- and amphetamine-regulated transcript protein

A redox-regulated disulphide may form within Cocaine- and amphetamine-regulated transcript protein between cysteines 82 and 115 (55 and 88 respectively in this structure).

Details

Redox score ?
75
PDB code
1hy9
Structure name
cocaine and amphetamine regulated transcript
Structure deposition date
2001-01-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16568
Residue number A
82
Residue number B
115
Peptide name
Cocaine- and amphetamine-regulated transcript protein

Ligandability

Cysteine 82 of Cocaine- and amphetamine-regulated transcript protein

Cysteine 115 of Cocaine- and amphetamine-regulated transcript protein

A redox-regulated disulphide may form within Cocaine- and amphetamine-regulated transcript protein between cysteines 88 and 102 (61 and 75 respectively in this structure).

Details

Redox score ?
75
PDB code
1hy9
Structure name
cocaine and amphetamine regulated transcript
Structure deposition date
2001-01-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16568
Residue number A
88
Residue number B
102
Peptide name
Cocaine- and amphetamine-regulated transcript protein

Ligandability

Cysteine 88 of Cocaine- and amphetamine-regulated transcript protein

Cysteine 102 of Cocaine- and amphetamine-regulated transcript protein

A redox-regulated disulphide may form within Cocaine- and amphetamine-regulated transcript protein between cysteines 88 and 115 (61 and 88 respectively in this structure).

Details

Redox score ?
71
PDB code
1hy9
Structure name
cocaine and amphetamine regulated transcript
Structure deposition date
2001-01-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16568
Residue number A
88
Residue number B
115
Peptide name
Cocaine- and amphetamine-regulated transcript protein

Ligandability

Cysteine 88 of Cocaine- and amphetamine-regulated transcript protein

Cysteine 115 of Cocaine- and amphetamine-regulated transcript protein

A redox-regulated disulphide may form within Cocaine- and amphetamine-regulated transcript protein between cysteines 108 and 115 (81 and 88 respectively in this structure).

Details

Redox score ?
70
PDB code
1hy9
Structure name
cocaine and amphetamine regulated transcript
Structure deposition date
2001-01-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16568
Residue number A
108
Residue number B
115
Peptide name
Cocaine- and amphetamine-regulated transcript protein

Ligandability

Cysteine 108 of Cocaine- and amphetamine-regulated transcript protein

Cysteine 115 of Cocaine- and amphetamine-regulated transcript protein

A redox-regulated disulphide may form within Cocaine- and amphetamine-regulated transcript protein between cysteines 82 and 102 (55 and 75 respectively in this structure).

Details

Redox score ?
69
PDB code
1hy9
Structure name
cocaine and amphetamine regulated transcript
Structure deposition date
2001-01-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16568
Residue number A
82
Residue number B
102
Peptide name
Cocaine- and amphetamine-regulated transcript protein

Ligandability

Cysteine 82 of Cocaine- and amphetamine-regulated transcript protein

Cysteine 102 of Cocaine- and amphetamine-regulated transcript protein

A redox-regulated disulphide may form within Cocaine- and amphetamine-regulated transcript protein between cysteines 82 and 88 (55 and 61 respectively in this structure).

Details

Redox score ?
68
PDB code
1hy9
Structure name
cocaine and amphetamine regulated transcript
Structure deposition date
2001-01-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16568
Residue number A
82
Residue number B
88
Peptide name
Cocaine- and amphetamine-regulated transcript protein

Ligandability

Cysteine 82 of Cocaine- and amphetamine-regulated transcript protein

Cysteine 88 of Cocaine- and amphetamine-regulated transcript protein

A redox-regulated disulphide may form within Cocaine- and amphetamine-regulated transcript protein between cysteines 82 and 108 (55 and 81 respectively in this structure).

Details

Redox score ?
64
PDB code
1hy9
Structure name
cocaine and amphetamine regulated transcript
Structure deposition date
2001-01-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16568
Residue number A
82
Residue number B
108
Peptide name
Cocaine- and amphetamine-regulated transcript protein

Ligandability

Cysteine 82 of Cocaine- and amphetamine-regulated transcript protein

Cysteine 108 of Cocaine- and amphetamine-regulated transcript protein

A redox-regulated disulphide may form within Cocaine- and amphetamine-regulated transcript protein between cysteines 100 and 115 (73 and 88 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
1hy9
Structure name
cocaine and amphetamine regulated transcript
Structure deposition date
2001-01-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16568
Residue number A
100
Residue number B
115
Peptide name
Cocaine- and amphetamine-regulated transcript protein

Ligandability

Cysteine 100 of Cocaine- and amphetamine-regulated transcript protein

Cysteine 115 of Cocaine- and amphetamine-regulated transcript protein

A redox-regulated disulphide may form within Cocaine- and amphetamine-regulated transcript protein between cysteines 88 and 100 (61 and 73 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
1hy9
Structure name
cocaine and amphetamine regulated transcript
Structure deposition date
2001-01-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16568
Residue number A
88
Residue number B
100
Peptide name
Cocaine- and amphetamine-regulated transcript protein

Ligandability

Cysteine 88 of Cocaine- and amphetamine-regulated transcript protein

Cysteine 100 of Cocaine- and amphetamine-regulated transcript protein

A redox-regulated disulphide may form within Cocaine- and amphetamine-regulated transcript protein between cysteines 100 and 102 (73 and 75 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
1hy9
Structure name
cocaine and amphetamine regulated transcript
Structure deposition date
2001-01-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16568
Residue number A
100
Residue number B
102
Peptide name
Cocaine- and amphetamine-regulated transcript protein

Ligandability

Cysteine 100 of Cocaine- and amphetamine-regulated transcript protein

Cysteine 102 of Cocaine- and amphetamine-regulated transcript protein

A redox-regulated disulphide may form within Cocaine- and amphetamine-regulated transcript protein between cysteines 100 and 108 (73 and 81 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
1hy9
Structure name
cocaine and amphetamine regulated transcript
Structure deposition date
2001-01-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16568
Residue number A
100
Residue number B
108
Peptide name
Cocaine- and amphetamine-regulated transcript protein

Ligandability

Cysteine 100 of Cocaine- and amphetamine-regulated transcript protein

Cysteine 108 of Cocaine- and amphetamine-regulated transcript protein

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