a tool for identifying drug-targetable redox-active disulphides

Frataxin, mitochondrial

Intermolecular

Cysteine 308 of Cysteine desulfurase and cysteine 50

A redox-regulated disulphide may form between cysteine 308 of Cysteine desulfurase and cysteine 50 of Frataxin, mitochondrial. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

25

PDB code

Structure name

architecture of the human mitochondrial iron-sulfur cluster assembly machinery: the complex formed by the iron donor, the sulfur donor, and the scaffold

Structure deposition date

2016-07-22

Thiol separation (Å)

10

Half-sphere exposure sum ?

83

Minimum pK_a ?

11

% buried

92

Peptide A name

Cysteine desulfurase

Peptide B name

Frataxin, mitochondrial

Peptide A accession

Peptide B accession

Peptide A residue number

308

Peptide B residue number

50

Ligandability

Cysteine 308 of Cysteine desulfurase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 50 of Frataxin, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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