ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Guanylate cyclase activator 2B

Intramolecular
Cysteine 103 and cysteine 111
Cysteine 100 and cysteine 108
Cysteine 100 and cysteine 103
Cysteine 103 and cysteine 108
Cysteine 108 and cysteine 111
Cysteine 100 and cysteine 111
A redox-regulated disulphide may form within Guanylate cyclase activator 2B between cysteines 103 and 111 (7 and 15 respectively in this structure).

Details

Redox score ?
91
PDB code
1uya
Structure name
the solution structure of the a-form of uroguanylin-16 nmr, 10 structures
Structure deposition date
1997-09-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
25
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16661
Residue number A
103
Residue number B
111
Peptide name
Guanylate cyclase activator 2B

Ligandability

Cysteine 103 of Guanylate cyclase activator 2B

Cysteine 111 of Guanylate cyclase activator 2B

A redox-regulated disulphide may form within Guanylate cyclase activator 2B between cysteines 100 and 108 (4 and 12 respectively in this structure).

Details

Redox score ?
90
PDB code
1uyb
Structure name
the solution structure of the b-form of uroguanylin-16 nmr, 10 structures
Structure deposition date
1997-09-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
29
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16661
Residue number A
100
Residue number B
108
Peptide name
Guanylate cyclase activator 2B

Ligandability

Cysteine 100 of Guanylate cyclase activator 2B

Cysteine 108 of Guanylate cyclase activator 2B

A redox-regulated disulphide may form within Guanylate cyclase activator 2B between cysteines 100 and 103 (4 and 7 respectively in this structure).

Details

Redox score ?
84
PDB code
1uyb
Structure name
the solution structure of the b-form of uroguanylin-16 nmr, 10 structures
Structure deposition date
1997-09-11
Thiol separation (Å)
3
Half-sphere exposure sum ?
30
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16661
Residue number A
100
Residue number B
103
Peptide name
Guanylate cyclase activator 2B

Ligandability

Cysteine 100 of Guanylate cyclase activator 2B

Cysteine 103 of Guanylate cyclase activator 2B

A redox-regulated disulphide may form within Guanylate cyclase activator 2B between cysteines 103 and 108 (7 and 12 respectively in this structure).

Details

Redox score ?
81
PDB code
1uya
Structure name
the solution structure of the a-form of uroguanylin-16 nmr, 10 structures
Structure deposition date
1997-09-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
27
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16661
Residue number A
103
Residue number B
108
Peptide name
Guanylate cyclase activator 2B

Ligandability

Cysteine 103 of Guanylate cyclase activator 2B

Cysteine 108 of Guanylate cyclase activator 2B

A redox-regulated disulphide may form within Guanylate cyclase activator 2B between cysteines 108 and 111 (12 and 15 respectively in this structure).

Details

Redox score ?
77
PDB code
1uyb
Structure name
the solution structure of the b-form of uroguanylin-16 nmr, 10 structures
Structure deposition date
1997-09-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
27
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16661
Residue number A
108
Residue number B
111
Peptide name
Guanylate cyclase activator 2B

Ligandability

Cysteine 108 of Guanylate cyclase activator 2B

Cysteine 111 of Guanylate cyclase activator 2B

A redox-regulated disulphide may form within Guanylate cyclase activator 2B between cysteines 100 and 111 (4 and 15 respectively in this structure).

Details

Redox score ?
61
PDB code
1uya
Structure name
the solution structure of the a-form of uroguanylin-16 nmr, 10 structures
Structure deposition date
1997-09-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
26
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16661
Residue number A
100
Residue number B
111
Peptide name
Guanylate cyclase activator 2B

Ligandability

Cysteine 100 of Guanylate cyclase activator 2B

Cysteine 111 of Guanylate cyclase activator 2B

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